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:: Volume 7, Issue 28 (10-2017) ::
NCMBJ 2017, 7(28): 105-113 Back to browse issues page
Determination of existence of oqxAB genes in Klebsiella pneumoniae isolated from urinary tract infections and their antibiotic resistance pattern in Qom
Saghar Shahbazi , Mohsen Zargar , Mohammad Soleimani dorjagh
Department of Microbiology, Faculty of Basic Science, Islamic Azad University Qom, Qom, Iran , zmohsen2002@yahoo.com
Abstract:   (887 Views)
Aim and Background: the efflux  pumps as one of the resistance mechanisms against  antibiotics. So object of this study, is determining the existence of oqxA and oqxB gens in Klebsiella pneumoniae Isolated and their sample of antibiotic resistance.                                                                                                                                                 
Materials and methods: the sample making of 500 referred outpatients to the laboratories of Qom province. For determining of antibiotic sensibility, it was according to instruction CLSI 2014. the existence of oqxA and oqxB genes was detected by PCR.
                                                      
Result: 100 number of  klebsiella pneumonie bacteria separated. Determined. all Klebsiella pneumonia were sensitive to  Ciprofloxacin and Amikacin. The results out of  PCR revealed 46% had oqxA gene and 52% had oqxB gene.                                                                                               
                                                                                                                                                       
Conclusion:. Results out of present study suggest that the klebsiella pneumonia bacteria in strains isolated in hospitals of Qom has got a very significant statisics. Also, efflux pumps oqxAB have got a relatively high quantity.                                                                                                                             
Results:The ways to confront and oppose antibiotic resistance including the efflux pumps oqxAB is important. These findings indicate the need to control the antibiotics treatments and to use new antibiotic agents for the treatment of infections caused by this bacteria and other resistant organisms.                                                                                        
Keywords: Klebsiella pneumonia- urinary trac infections- Antibiotic resistance- Efflux pump
Full-Text [PDF 456 kb]   (345 Downloads)    
Type of Study: Research Article | Subject: Genetics
Received: 2017/12/30 | Accepted: 2017/12/30 | Published: 2017/12/30
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Shahbazi S, Zargar M, Soleimani dorjagh M. Determination of existence of oqxAB genes in Klebsiella pneumoniae isolated from urinary tract infections and their antibiotic resistance pattern in Qom. NCMBJ. 2017; 7 (28) :105-113
URL: http://ncmbjpiau.ir/article-1-1038-en.html


Volume 7, Issue 28 (10-2017) Back to browse issues page
مجله تازه های بیوتکنولوژی سلولی - مولکولی New Cellular and Molecular Biotechnology Journal
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