Volume 2, Issue 5 (New Cellular and Molecular Biotechnology 2011)                   NCMBJ 2011, 2(5): 9-13 | Back to browse issues page

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Bozorgnejad A, Baghi F, Akbarzadeh A, Arjmand M. A nano Carrier Extracted from Archaea Called Archaeosome Examination of Cisplatin Loading. NCMBJ. 2011; 2 (5) :9-13
URL: http://ncmbjpiau.ir/article-1-119-en.html
science and research branch, Islamic Azad University , abnejad62@gmail.com
Abstract:   (23842 Views)

Aim and Background. Archaeosome is known as a new lipid carrier for targeted drug delivery in cancer therapy. The anti cancer drug , Cisplatin , is encapsulated in archaeosome to reduce the side effects of drug on other cells and offer more dosage of drug on target cell

Material and Method. Archaeosome was extracted from methanogens and after being dissolved in phosphate buffer, the solution was sonicated in bath sonicator for loading the cisplatin on extracted archaeosome and resize to nano scale.

Results. Mass balance was obtained using density and molecular weight of sonicated solution elements, and therefore, the loading percentage of drug on nano archaeosome was obtained. The particles size in nano scale was confirmed with zeta sizer.

Conclusion. The main purpose of this research was to load cisplatin on archaeosome for targeted drug delivery against cancer. We obtained very suitable loading percentage that allowed us to succeed in our aim.

Full-Text [PDF 174 kb]   (320 Downloads)    
Type of Study: Research Article | Subject: Microbiology
Received: 2012/04/12

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