Volume 16, Issue 62 (5-2026)
NCMBJ 2026, 16(62): 99-111 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Hoveida R, Mohebifar A, Panah Yazdan S. Evaluation of the Effect of Twelve Weeks of Pilates Exercise on Serum Interleukin-10 (IL-10) and Interleukin-1 Beta (IL-1β) Levels in Women with Multiple Sclerosis (MS). NCMBJ 2026; 16 (62) :99-111
URL: http://ncmbjpiau.ir/article-1-1825-en.html
URL: http://ncmbjpiau.ir/article-1-1825-en.html
Young Researchers and Elites Club, Department of Biology, Islamic Azad University, Varamin Branch, Peshwa, Tehran, Iran
Abstract: (23 Views)
Background and Aim: Multiple sclerosis (MS) is a chronic, progressive autoimmune disease characterized by inflammation of the central nervous system and dysregulation of immune responses. In the pathophysiology of MS, pro-inflammatory cytokines such as interleukin-1 beta (IL-1β) and anti-inflammatory cytokines like interleukin-10 (IL-10) play critical roles. This study aimed to evaluate the effect of a twelve-week Pilates training program on serum levels of IL-10 and IL-1β in women with MS.
Materials and Methods: This quasi-experimental study with a pre-test–post-test design and a control group was conducted on 18 women with relapsing-remitting MS. Participants were randomly assigned to either an experimental group (n=9) or a control group (n=9). The experimental group underwent supervised Pilates training for 12 weeks, three sessions per week. Venous blood samples were collected before and after the intervention. Serum levels of IL-10 and IL-1β were assessed using the ELISA method. Data were analyzed using paired and independent t-tests in SPSS version 21.
Results: In the experimental group, IL-10 levels significantly increased (p=0.02), while IL-1β levels showed a non-significant decrease (p=0.08). No significant changes were observed in the control group.
Conclusion: The findings suggest that regular Pilates exercise may enhance immune regulation and reduce systemic inflammation in women with MS by increasing IL-10 and moderately reducing IL-1β levels.
Materials and Methods: This quasi-experimental study with a pre-test–post-test design and a control group was conducted on 18 women with relapsing-remitting MS. Participants were randomly assigned to either an experimental group (n=9) or a control group (n=9). The experimental group underwent supervised Pilates training for 12 weeks, three sessions per week. Venous blood samples were collected before and after the intervention. Serum levels of IL-10 and IL-1β were assessed using the ELISA method. Data were analyzed using paired and independent t-tests in SPSS version 21.
Results: In the experimental group, IL-10 levels significantly increased (p=0.02), while IL-1β levels showed a non-significant decrease (p=0.08). No significant changes were observed in the control group.
Conclusion: The findings suggest that regular Pilates exercise may enhance immune regulation and reduce systemic inflammation in women with MS by increasing IL-10 and moderately reducing IL-1β levels.
Type of Study: Research Article |
Subject:
Physiology
Received: 2026/06/22 | Accepted: 2026/05/31 | Published: 2026/05/31
Received: 2026/06/22 | Accepted: 2026/05/31 | Published: 2026/05/31
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |