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Aim and Background: The production of Extended Spectrum Beta Lactamases (ESBLs) by Escherichia coli is the main cause of resistance to Cephalosporins , Worldwide has tremendously increased. The aim of this study was to determine the prevalence of ESBL-producing E. coli and antibiotic resistance patterns of those. Materials and Methods: In this study, 196 cases of E. coli within 6 months from patients referring to the public and private treatment centers Marand city were collected and identified by biochemical tests. ESBL screening and confirmation along with antimicrobial susceptibility test was done according to the Clinical Laboratory Standards Institute (CLSI) guidelines. Results: Of 196 isolates, 100 isolates (51.02%) were produced ESBL. 82% of the isolates were resistant to Ampicillin and 76% of the isolates were Sensitive to Imipenem. Conclusions: Organisms expressing ESBLs in this study were widely distributed, often possessing the multidrug resistance phenotype. Limiting the use of broad-spectrum Cephalosporins is recommended to control this high rate of ESBL expression.

Keywords: E. coli, Extended Spectrum Beta Lactamase, Disk diffusion method, Drug Resistance

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