Aim and Background. Archaeosome is known as a new lipid carrier for targeted drug delivery in cancer therapy. The anti cancer drug , Cisplatin , is encapsulated in archaeosome to reduce the side effects of drug on other cells and offer more dosage of drug on target cell

Material and Method. Archaeosome was extracted from methanogens and after being dissolved in phosphate buffer, the solution was sonicated in bath sonicator for loading the cisplatin on extracted archaeosome and resize to nano scale.

Results. Mass balance was obtained using density and molecular weight of sonicated solution elements, and therefore, the loading percentage of drug on nano archaeosome was obtained. The particles size in nano scale was confirmed with zeta sizer.

Conclusion. The main purpose of this research was to load cisplatin on archaeosome for targeted drug delivery against cancer. We obtained very suitable loading percentage that allowed us to succeed in our aim.

Aim and Background. The main purpose of this research is cisplatin loading on liposome for targeted drug delivery. The suitable loading percentage obtained showed that we have achieved the target.

Material and Methods. Liposome was extracted from a lecithin source and after dissolving in phosphate buffer the solution was sonicated in bath sonicator for loading the cisplatin on extracted liposomes and resizing to nano scale.

Results. Total amount of plating in sonicated solution is known. Platin which exists in solution transparent phase after ultra centrifuge process, was determined with atomic absorption test. By subtracting these two amounts from each other we achieved the amount of platin existed in sedimentation phase. Particles’ size in nano scale were confirmed with zeta sizer.

Conclusion. Liposome is known as a new lipid carrier for targeted drug delivery in cancer therapy. The anti cancer drug “cisplatin”, was encapsulated in liposome to reduce the side effects of drug on other cells and have a more dosage of drug on target cell.

Aim and Background. The purpose of this research is to have increased level of stability and fatality rate of cisplatin by application of encapsulation process in nanoarchaeosome. Success of this research is proved by examining the results obtained from MTT tests on Breast cancer cells in MCF-7 cell line.

Materials and Methods. After cultivation of MCF-7 cell line in culture room, fatality rate of encapsulated cisplatin was compared with normal cisplatin by performing the related MTT tests. Output numbers from Elisa Reader explained the death rate of cancer cells.

Results. During the MTT tests performed on MCF-7 cell line, effect rate of encapsulated cisplatin was compared with normal cisplatin. Examining the figures resulted from Elisa Reader output numbers, shows that stability and fatality rate of encapsulated drug is extremely higher than normal drug.

Conclusion. Nanoarchaeosome is used for encapsulating of cisplatin. This process causes increasing the stability of drug in addition to the rise of fatality rate. This was clearly shown by examining the Breast cancer cells in MCF-7 cell line.