fa پیری سلولی و بیوتکنولوژی سلولی و مولکولی Cellular and molecular مقاله مروری Review Article <p style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt" dir="rtl" class="BasicParagraph" align="justify"><font face="times new roman,times,serif"><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">Senescence</span><span dir="rtl"></span><span style="mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE"><span dir="rtl"></span><font size="2"> فرآیند بدتر شدنِ همراه با پیری است. پیری در سطوح مختلف بافت و اندام، سلول و مولکول بروز می کند. عوامل متعددی در بروز پیری نقش دارند که شامل زمینه ژنتیکی، میزان تولید رادیکال های آزاد، میزان فعالیت آنزیم تلومراز، محدودیت غذایی، تولید محصولات زائد، متیلاسیون </font></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">DNA</span><span dir="rtl"></span><span style="mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE"><span dir="rtl"></span><font size="2">، گلیکاسیون، استرس، جهش های میتوکندریایی، تخریب و ترمیم </font></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">DNA</span><span dir="rtl"></span><span style="mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE"><span dir="rtl"></span><font size="2">، میان کنش </font></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">DNA</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE"><span dir="rtl"></span>-</span><font size="2"><span style="mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE">پروتئین و غیره است که در علمی به نام</span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE"> </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">Gerantology</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi"><span dir="rtl"></span> </span><span style="mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE">جداگانه مورد مطالعه قرار می گیرند. استراتژی عمده ایجاد پیری در مخمر و جانوران پیام رسانی انسولین، جریان متابولیسمی، پایداری ژنومی، فعالیت تلومراز، تخریب و ترمیم </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">DNA</span><span dir="rtl"></span><span style="mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE"><span dir="rtl"></span>، هیستون استیلازها، هیستون دِاستیلازها و رادیکال های آزاد است، اما در گیاهان فیتوهورمون ها، ماشین فتوسنتزی و تخریب پروتئین در ایجاد پیری نقش اصلی دارند. بیماری های مرتبط با سن مانند آرتریت روماتوئید، سرطان ها، ناهنجاری های عصبی و افتادگی پوست، هزینه ای است که ما برای زندگی طولانی مدت باید بپردازیم. امروزه بیوتکنولوژی در ارتباط با پیری سلولی و مبارزه با بیماری های ناشی از سن در 2 زمینه به انسان کمک می کند: </span></font></font><span style="mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE"><font size="2"><font face="times new roman,times,serif">1) شناسایی کاهش روند پیری و افزایش طول عمر سالم. اهداف دارویی شامل پروتئین های تحریک کننده و مهارکننده آپوپتوزیس، واکسن های ضد عوامل عفونی و سرطان ها، پروتئین های نوترکیب و هورمون درمانی، مهار کننده های آنزیم های موثر در التهاب، تولید سلول، بافت و حتی اندام، پروتئین های اسکلت سلولی، فعالیت ژن های موثر در افزایش و کاهش طول عمر و غیره است. </font></font></span><font size="2"><font face="times new roman,times,serif"><span style="mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE">2) ایجاد روند پیری و مرگ در سلول های بدخیم، سرطانی و عفونی و ردیابی درمان. اهداف دارویی شامل پتانسیل غشاء و پروتئین های میتوکندری، فعالیت آنزیم تلومراز، پروتئین های مهار کننده و تحریک کننده آپوپتوزیس و غیره است. برای انجام موارد فوق بیوتکنولوژی خود به روش ها و تکنیک هایی نظیر </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">RNAi</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE"><span dir="rtl"></span> ،</span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">Drug</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi"><span dir="rtl"></span> </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">Delivery</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi"><span dir="rtl"></span> </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">techniques</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE"><span dir="rtl"></span>, </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">Nano</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi"><span dir="rtl"></span> </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">materials</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE"><span dir="rtl"></span> ،</span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">DNA</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi"><span dir="rtl"></span> </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">vaccines</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE"><span dir="rtl"></span> ،</span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">Recombinant</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi"><span dir="rtl"></span> </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">antibody</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi"><span dir="rtl"></span> </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">Hormone</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi"><span dir="rtl"></span> </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">therapy</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE"><span dir="rtl"></span> ،</span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">Cell</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi"><span dir="rtl"></span> </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">therapy</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE"><span dir="rtl"></span>، </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">Gene</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi"><span dir="rtl"></span> </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">therapy</span><span dir="rtl"></span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE"><span dir="rtl"></span> و </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">Tissue</span><span dir="rtl"></span><span style="mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi"><span dir="rtl"></span> </span><span style="LINE-HEIGHT: 120% FONT-SIZE: 10pt mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" dir="ltr">engineering</span><span dir="rtl"></span><span style="mso-ascii-font-family: 'Times New Roman' mso-ascii-theme-font: major-bidi mso-hansi-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-font-family: 'Times New Roman' mso-bidi-theme-font: major-bidi" lang="AR-YE"><span dir="rtl"></span> وابسته است.</span></font></font></p> <p style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: ltr" class="BasicParagraph"><font face="Times New Roman"><font size="2"><span><strong>Aim and background.</strong> The ageing or senescence is a complex process involving<span dir="rtl"></span><span dir="rtl"><span dir="rtl"></span> </span>biologi</span><span style="mso-ansi-language: CS" lang="CS">cal <span style="LETTER-SPACING: -0.1pt">changes in tissue, organ, cell and molecule levels, the eventual decline of which<span dir="rtl"></span><span dir="rtl"><span dir="rtl"></span> </span>ultima</span>tely leads to death of organism. The mechanisms by which a cell ultimately defines the end of <span style="LETTER-SPACING: -0.5pt">its life span and ceases to involve factors including genetic context, free radicals, telome</span>rase<span dir="rtl"></span><span dir="rtl"><span dir="rtl"></span> </span>activity, caloric restriction, waste productions, DNA methylation, glycation, stress,<span dir="rtl"></span><span dir="rtl"><span dir="rtl"></span> </span>mtDNA mutations, damage and DNA repair, DNA-protein interactions, etc which are </span></font></font><span style="mso-ansi-language: CS" lang="CS"><font face="Times New Roman"><font size="2">regarded as a new science namely Gerantology. The most important cell ageing strategies in yeast and animals are insulin signaling, metabolic flow, genome stability,telomerase activity, damage and DNA repair, histone acetylases, histone deacetylases and free radicals, but in plants phytohormones, photosynthetic machine and protein damage affect cell ageing. Age-related diseases such as rheumatoid arthritis, cancers, neural disorders, skin lose, etc are the cost of longevity. Nowadays, biotechnology in two aspects would help us namely for the conflicting with age-related diseases and cell ageing:1) Detection, decrease of ageing process and increase of health longevity. 2) Creation of ageing process and death in malignant, cancerous, infectious cells and assessment of treatments.In order for Biotechnology to accomplish the above cases successfully needs RNAi, Drug delivery techniques, nano materials, DNA vaccines, Recombinant antibodies, hormone, cell and gene therapy, tissue engineering and other procedures and techniques.<p></p></font></font></span></p> Cell Therapy, Ageing, Biotechnology, Apoptosis, Senescence, Gerantology, RNAi Ageing, Biotechnology, Apoptosis, Senescence, Gerantology, RNAi, Cell Therapy 7 26 http://ncmbjpiau.ir/browse.php?a_code=A-10-61-2&slc_lang=fa&sid=1 Reza Yari رضا یاری REZAYARI@YAHOO.COM 0384554806 1003194753284600662 Yes Department of Biology, Islamic Azad University, Boroujerd Branch, Boroujerd, Iran دانشگاه آزاد بروجرد