The roles of HMGB1 nuclear protein and its major domains in different biological fields

Talebi , Somayeh; Bolhassani , Azam; Mokhtari Azad, Talat; Arashkia , Arash; Modarressi , Mohammad Hossein

Volume 8, Issue 29 (1-2018) NCMBJ 2018, 8(29): 9-22 | Back to browse issues page

‎ 20.1001.1.22285458.1396.8.29.1.0

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Talebi S, Bolhassani A, Mokhtari Azad T, Arashkia A, Modarressi M H. The roles of HMGB1 nuclear protein and its major domains in different biological fields . NCMBJ 2018; 8 (29) :9-22
URL: http://ncmbjpiau.ir/article-1-1053-en.html

The roles of HMGB1 nuclear protein and its major domains in different biological fields

Somayeh Talebi

, Azam Bolhassani

, Talat Mokhtari Azad

, Arash Arashkia

, Mohammad Hossein Modarressi

Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran , azam.bolhassani@yahoo.com

Abstract: (6917 Views)

HMGB1 protein is an intracellular protein that translocated into the nucleus and regulates genes expression. HMGB1 plays multi-functional roles through recombination, transcriptional regulation, and inflammation. HMGB1 binds to cyclin-dependent kinase such as CDK2 that regulates the transcription of genes associated with the progression of cell cycle. In addition, HMGB1 as a novel cytokine plays major role in inflammation and arthritis. Recently, the role of HMGB1 protein as an adjuvant and stimulating both humoral and cellular immune responses has been proven in viral infections such as HIV-1 and influenza. Several studies indicated that Hp91, a HMGB1-derived peptide, stimulates efficiently DC maturation, and boosts the cellular and humoral immune responses in vivo. Our recent data also showed that the full length of HMGB1 gene, and Hp91 peptide could be an effective adjuvant in developing the therapeutic HPV DNA- and protein-based vaccines, respectively. In this review, the structure and functions of HMGB1 is described in molecular biology and medicine.

Keywords: Endogenous adjuvant, HMGB1, Hp91, Biological activity

Full-Text [PDF 641 kb] (4851 Downloads)

Type of Study: Research Article | Subject: Genetics
Received: 2018/02/27 | Accepted: 2018/02/27 | Published: 2018/02/27