Volume 6, Issue 24 (10-2016)                   NCMBJ 2016, 6(24): 37-42 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ramezani M, Rezaei S, Nasri S, Hooshyar L. Investigation the effects of silver nano particles on ovary tissue and HPG axis in rats. NCMBJ 2016; 6 (24) :37-42
URL: http://ncmbjpiau.ir/article-1-892-en.html
Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran , mina.ramezani@gmail.com
Abstract:   (7430 Views)

Aim and Background: By attention to extensive use of Silver nanoparticles, this study has been done to investigate the effects of silver these particles on ovary tissue and HPG axis.

Materials and Methods:Adult female rats were divided into five groups. Treatment groups received 25, 50, 100, and 200 mg/kg/day silver nano particles for 30 days orally. Then the rats weighed and levels of FSH, LH, estrogen, and progesterone were measured. Ovaries sections were studied using light microscopy.

Results: The weight of rats and their ovaries, the level of FSH, LH, and Estrogen of serum decreased significantly in 50,100, and 200 mg/kg doses in comparison with the control (p<0.05).  However, progesterone almost remained unaffected. Ovary tissue examination in the group that had been given a high dose of silver nanoparticles indicated extensive congestion comparing with control. Moreover, the number of the follicles had been reduced. These results were also observable in lower doses in moderate degree.  

Conclusion:Results have indicated poisonous effects of silver nanoparticles on HPG-axis and ovary tissue that is dose dependent. Therefore, enough precaution must be down in chronic exposure of females.

Full-Text [PDF 617 kb]   (2782 Downloads)    
Type of Study: Research Article | Subject: Histology
Received: 2017/02/1 | Accepted: 2017/02/1 | Published: 2017/02/1

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | New Cellular and Molecular Biotechnology Journal

Designed & Developed by : Yektaweb