TY - JOUR T1 - A new therapeutic approach for the treatment of breast cancer using synthesis of liposomes containing silybinin and their characterization TT - رویکرد درمانی نوین جهت درمان سرطان پستان با استفاده از سنتز لیپوزوم‌های حاوی سیلیبینین و مشخصه یابی آنها JF - NCMBJ JO - NCMBJ VL - 11 IS - 44 UR - http://ncmbjpiau.ir/article-1-1417-en.html Y1 - 2021 SP - 57 EP - 70 KW - Breast cancer KW - liposome KW - silybinin KW - Encapsulation KW - Slow release KW - Iau Science. N2 - Aim and Background: Silybinin, one of the active pharmaceutical ingredients in some medical herbs, has been proven to have anti-cancer effects. The aim of this study was to synthesis and characterize lipid nano-carriers containing silybinin in order to breast cancer treatment. Material and Methods: Lipid nanocarriers were synthesized using a thin film method and the drug was loaded on them. Then the physicochemical properties were evaluated using DLS, AFM and spectrophotometers and their toxicity was measured in comparison with the free form of the drug by MTT assay on BT-474 breast cancer cell line. Results: The synthesized nano-system with a size of 113.2 nm, zeta potential of -22 ± 1.63 mV, slow release type with appropriate physicochemical properties improves the anti-cancer effects of drug on breast cancer cells. Conclusion: The results of this study demonstrated that the synthesized system, in addition to having appropriate physicochemical properties, could improve anti-cancer effect of drug. M3 ER -