TY - JOUR T1 - Study the Probiotic Effects of Lactobacillus Plantarum on Cutaneous Wound Healing in Rat TT - بررسی اثرات پروبیوتیک لاکتوباسیلوس پلانتاروم بر ترمیم زخم پوستی در رت JF - NCMBJ JO - NCMBJ VL - 1 IS - 1 UR - http://ncmbjpiau.ir/article-1-5-en.html Y1 - 2011 SP - 21 EP - 27 KW - Cutaneous wound KW - Probiotic KW - Healing KW - Lactobacillus palantarum KW - Exopolysaccharid N2 -  Aim and Background. Probiotics are microorganisms in the gastrointestinal tract that besides helping the digestion of complex molecules, also helped the immune system and will reduce inflammation. The beneficial effects of these bacteria on ulcer healing has been proved but little research has been don done in the field of healing effects of these bacteria on cotaneous wound healing. Therefore, the purpose of this experiment is study the effect of lactobacillus plantarum isolated from Iranian traditional dairy products on cutaneous wound healing. Materials and Methods. After isolated 22 strains of lactobacillus from Iranian traditional-dairy products and measuring exopolysaccharide production in stains by phenol-sulfuric acid method eventually, Lactobacillus plantarum selected because it has a high exopolysaccharide (EPS) production. Wistar male rats divided into 3 groups experimental, control and negative control (n=5) and a full-thickness wound   (1.5 × 1.5 cm) was made on the back of each rat (45 rats in 3 groups). After 24 hours of injury, Two groups, control and experimental, were treated by eucerin and eucerin contained lactobacillus plantarum, respectively, but the negative-control group did not receive anything. On days 1, 3 and 14 rats were killed and wound samples were collected for histological and statistical studies. Results . Lactobacillus plantarum significantly decreased wound area compared to control and negative control groups and increased wound healing. Histological study on day 3 showed significant increase in  number of neutrophils and significant increases in macrophages and fibroblasts (p M3 ER -