RT - Journal Article T1 - The role of curcumin in protection of induced TDS( testicular dysgensis syndrome ) testicular cells by phthalate in mice JF - NCMBJ YR - 2017 JO - NCMBJ VO - 7 IS - 28 UR - http://ncmbjpiau.ir/article-1-1034-en.html SP - 69 EP - 77 K1 - Anti oxidant K1 - curcumin K1 - DHEA K1 - sertoli cells K1 - phthalate K1 - TDS K1 - testosterone AB - Aim and Background: Curcumin is the yellow pigment derived from rhizome of turmeric. Curcuminoids are natural phenols that used in natural medicine for thousands of years. Currently antioxidant and anti-inflammatory properties of this material are considered in clinical practice. However, a little study that has been done on the effect of curcumin on a reproductive system. Materials and methods: This study was an experimental study, 40 male NMRI mice weighing 20 to 30 grams were investigated. The rats were randomly assigned to four groups: control, treated with 10mg / kg / Day DEHP, DEHP treatment group with curcumin and curcumin group. After two weeks body weight of mice were measured. Right and left testis was weighed separately. The genital pore distance (AGD) was measured. The blood was drived from the heart, testosterone, and dehydroepiandrosterone performed by ELISA Mehod on mice serum. Testicular samples were cutting 5 microns and stained with hematoxilina-eosina method, ultimately were evaluated. Results: The study demonstrated protective effects of Curcumin on testis of mice. So that daily administration DEHP10mg / kg / day with 5 ml curcumin can improve the parameters of body weight (p = 0.000), testicular right and left (p = 0.000) and serum testosterone (p = 0.026) compared to mice treated with DEHP was alone. Also microscopic pathological waste, including demolition of Sertoli cells and Leydig cell necrosis in the group treated with DEHP was found in the group treated with curcumin + DEHP were improved. Conclusion: Curcumin protects testicular tissue from free radicals induced of phthalates by antioxidant properties. It also modulates the testoster hormone as a regulator of reproduction, weight and growth process. LA eng UL http://ncmbjpiau.ir/article-1-1034-en.html M3 ER -