fa بررسی نانوکامپوزیت پلی وینیل الکل/کتیرا/Fe3O4 (PVA/GT/Fe3O4) جهت انتقال هدفمند داروی هیدروکسی کلروکین (HCQ) فیزیولوژی Physiology مقاله پژوهشی Research Article <span style="font-size:10pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span antiqua="" book="" style="font-family:"><b><span lang="FA" style="font-size:16.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">سابقه و هدف:</span></span></span></b><b> </b><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">یکی از داروهای کمکی برای درمان بیماری </span></span></span><b><a href="https://fa.wikipedia.org/wiki/%D9%85%D8%A7%D9%84%D8%A7%D8%B1%DB%8C%D8%A7"><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="color:black"><span style="font-weight:normal"><span style="text-decoration:none"><span style="text-underline:none">مالاریا</span></span></span></span></span></span></a></b><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">، برخی از تومورهای سرطانی و ویروس&shy;ها، داروی هیدروکسی کلروکین</span></span></span><b><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> (</span></span></span></b><span dir="LTR" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">HCQ</span></span></span><b><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">) </span></span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">است. جهت انتقال این دارو به سایت هدف، کنترل دوز و کاهش آسیب</span></span></span><span dir="LTR" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">&shy;</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">های سلولی، می&shy;توان از سیستم&shy;های دارورسانی هدفمند استفاده نمود. در این پروژه نانوکامپوزیت مغناطیسی </span></span></span><span dir="LTR" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">PVA/GT/Fe₃O₄</span></span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> بر پایه هیدروژل&shy;های </span></span></span><span dir="LTR" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">PVA</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> و </span></span></span><span dir="LTR" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">GT</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> تولید شده است که در آن نانوذرات مغناطیسی </span></span></span><span dir="LTR" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Fe₃O₄</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بارگذاری شده و پارامترهایی از جمله میزان </span></span></span><span dir="LTR" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Fe₃O₄</span></span></span><b>&nbsp;</b><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">و مقدار کراس لینک کننده بر نرخ رهایش دارو بررسی شده است.</span></span></span><b> </b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:16.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">مواد و روش&shy; ها:</span></span></span></span></b><b> </b><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">نانوکامپوزیت </span></span></span></span><span dir="LTR" style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:black">PVA/GT/Fe₃O₄</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black"> جهت انتقال داروی </span></span></span></span><span dir="LTR" style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:black">HCQ</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black"> تولید شد و نرخ رهایش دارو توسط این نانوکامپوزیت در </span></span></span></span><span dir="LTR" style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:black">pH</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black"> 4/7 و در بازه&shy;های زمانی مختلف به کمک دستگاه </span></span></span></span><span dir="LTR" style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:black">UV-Vis</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black"> بررسی شد. از طرفی دیگر جهت بهینه&shy;سازی ساختار نانوکامپوزیت، تأثیر میزان نانوذرات </span></span></span></span><span dir="LTR" style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Fe₃O₄</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black"> و مقدار مالئیک انیدرید در تورم نانوکامپوزیت و انتشار دارو مورد بررسی قرار گرفت.</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:16.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">یافته&shy; ها:</span></span></span></span></b><b> </b><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">با توجه به نتایج بدست آمده از </span></span></span></span><span dir="LTR" style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:black">FTIR</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black"> می توان به </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">برهمکنش </span></span></span></span><span dir="LTR" style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:black">PVA</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black"> با کتیرا پی برد.</span></span></span></span><b> </b><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">افزایش </span></span></span></span><span dir="LTR" style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Fe₃O₄</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black"> تورم را به میزان بالایی کاهش داد و میزان انتشار دارو را تا 2 برابر افزایش داد. افزایش مقدار اتصال دهنده عرضی نرخ انتشار دارو را کاهش داد. در طول 6 ساعت بیشترین میزان انتشار تجمعی دارو متعلق به نانوکامپوزیت</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black"> حاوی </span></span></span></span><span dir="LTR" style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:black">wt%</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">4</span></span></span></span><b> </b><span dir="LTR" style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Fe₃O₄</span></span></span><b> </b><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">بود(92/13 درصد).</span></span></span></span><b><span dir="LTR" style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:18.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">بحث:</span></span></span></span></b><b> </b><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">تورم نانوکامپوزیت به&shy;شدت به&shy;میزان </span></span></span></span><span dir="LTR" style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Fe₃O₄</span></span></span><span style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black"> وابسته است دلیل آن می&shy;تواند </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">مسدود شدن خلل و فرج هیدروژل جهت جذب آب باشد</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">. افزایش میزان اتصال دهنده عرضی باعث کاهش رهایش دارو شد که </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">ممکن است به دلیل کاهش انبساط شبکه هیدروژلی جهت رهایش دارو باشد.</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:16.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">نتیجه&shy; گیری:</span></span></span></span></b> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black">نانوکامپوزیت </span></span></span></span><span dir="LTR" style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:black">PVA/GT/Fe₃O₄</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black"> می تواند میزان انتشار دوز مشخصی از داروی </span></span></span></span><span dir="LTR" style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:black">HCQ</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black"> را کنترل می&shy;نماید و عوارض جانبی آن را کاهش دهد در نتیجه می&shy;تواند به&shy;عنوان حامل دارو جهت درمان بیماری&shy;های مرتبط بررسی شود که نیازمند مطالعه&shy;های بالینی است.</span></span></span></span><span lang="FA" style="font-size:16.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:12pt"><span style="background:white"><span style="tab-stops:0cm 237.05pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="color:black"><span style="letter-spacing:-.1pt">Aim and Background</span></span></b><b><span style="color:black">:</span></b><b> </b><span style="font-size:11.0pt"><span style="color:black">HCQ is one of the auxiliary drugs for the treatment of malaria, some cancerous tumors and viruses. Targeted drug delivery systems can be used to deliver the drug to the target site, controlling the dose and reducing cell damage. In this project, a magnetic nanocomposite for drug transfer was produced and investigated.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="background:white"><span style="tab-stops:0cm"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="color:black">Material and methods:</span></b> <span style="font-size:11.0pt"><span style="color:black">PVA/GT /</span></span><span style="font-size:11.0pt"><span style="color:black">Fe₃O₄ </span></span><span style="font-size:11.0pt"><span style="color:black">nanocomposite was produced for HCQ drug delivery and the drug release rate of this nanocomposite was evaluated at pH 7.4 and at different times. In order to optimize the nanocomposite, the effect of </span></span><span style="font-size:11.0pt"><span style="color:black">Fe₃O₄ </span></span><span style="font-size:11.0pt"><span style="color:black">and maleic anhydride nanoparticles on the swelling of the nanocomposite and drug release was investigated.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="background:white"><span style="tab-stops:0cm"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="color:black">Results:</span></b> <span style="font-size:11.0pt"><span style="color:black">Drug release is highly dependent on the amount of Fe3O4 and crosslinker, which can be controlled by changing the dose of nanocomposite. The highest cumulative drug release belonged to nanocomposites containing 4% wt </span></span><span style="font-size:11.0pt"><span style="color:black">Fe₃O₄ </span></span><span style="font-size:11.0pt"><span style="color:black">during 6 hours (13.92%).</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="tab-stops:0cm"><span style="text-autospace:none"><span style="line-height:107%"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion:</span></span></span></span></b> <span new="" roman="" style="font-family:" times=""><span style="color:black">PVA/GT /Fe₃O₄ nanocomposites can control the release of a certain dose of HCQ drug and reduce its side effects, so it can be considered as a drug carrier for the treatment of related diseases that require clinical studies.</span></span></span></span></span></span></span></span><br> &nbsp; Nanocomposite, HCQ, release, swelling, Iau Science. 23 34 http://ncmbjpiau.ir/browse.php?a_code=A-10-1738-2&slc_lang=fa&sid=1 Ali Zandi علی زندی 100319475328460013650 100319475328460013650 No Chemistry Department, Najafabad Branch, Islamic Azad University, Najafabad, Iran گروه شیمی، واحد نجف آباد، دانشگاه آزاد اسلامی، نجف آباد، ایران Hossein Abbas Tabar Ahangar حسین عباس تبار آهنگر abbastabar@pmt.iaun.ac.ir 100319475328460013651 100319475328460013651 No Chemistry Department, Najafabad Branch, Islamic Azad University, Najafabad, Iran گروه شیمی، واحد نجف آباد، دانشگاه آزاد اسلامی، نجف آباد، ایران Ali Saffar علی صفار 100319475328460013652 100319475328460013652 Yes Chemistry Department, Najafabad Branch, Islamic Azad University, Najafabad, Iran گروه شیمی، واحد نجف آباد، دانشگاه آزاد اسلامی، نجف آباد، ایران