New Cellularand Molecular Biotechnology Journal
مجله تازه هاي بيوتكنولوژي سلولي و مولكولي
NCMBJ
Basic Sciences
http://ncmbjpiau.ir
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2228-5458
2228-6926
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2025
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نقش پلیفنلها در تعدیل مسیرهای پیامرسانی سلولی در ردههای سلولی مرتبط با سرطان معده
The Role of Polyphenols in Modulating Cell Signaling Pathways in Gastric Cancer-Related Cell Lines
سلولی و مولکولی
Cellular and molecular
مقاله پژوهشی
Research Article
<span style="font-size:12pt"><span style="line-height:normal"><span style="tab-stops:right 468.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="font-family:"B Nazanin"">پلیفنل</span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Calibri","sans-serif""></span></span><span lang="FA" style="font-family:"B Nazanin"">ها بهعنوان یکی از منابع مهم آنتیاکسیدان</span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Calibri","sans-serif""></span></span><span lang="FA" style="font-family:"B Nazanin"">ها نقش بسزایی در فعلوانفعالات زیستی دارند. سرطان که یکی از جدی</span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Calibri","sans-serif""></span></span><span lang="FA" style="font-family:"B Nazanin"">ترین بیماری</span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Calibri","sans-serif""></span></span><span lang="FA" style="font-family:"B Nazanin"">های درگیرکنندۀ جوامع بشری است و پلیفنل</span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Calibri","sans-serif""></span></span><span lang="FA" style="font-family:"B Nazanin"">ها نقش مؤثری در القای مرگ سلولی و مهار تکثیر سلول</span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Calibri","sans-serif""></span></span><span lang="FA" style="font-family:"B Nazanin"">ها در مطالعههای درونتنی و برونتنی از خود نشان دادهاند. علی</span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Calibri","sans-serif""></span></span><span lang="FA" style="font-family:"B Nazanin"">رغم تلاش</span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Calibri","sans-serif""></span></span><span lang="FA" style="font-family:"B Nazanin"">های بسیار و استفاده از روش</span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Calibri","sans-serif""></span></span><span lang="FA" style="font-family:"B Nazanin"">های شیمیدرمانی و رادیوتراپی همچنان ارائۀ یک روش کارآمد برای درمان سرطان معده با ضریب موفقیت بالا هدف بسیاری از مطالعهها می</span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Calibri","sans-serif""></span></span><span lang="FA" style="font-family:"B Nazanin"">باشد.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:normal"><span style="tab-stops:right 468.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="font-family:"B Nazanin"">در این مطالعه که با استفاده از منابع دست اولِ موجود در دادۀ بانک</span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Calibri","sans-serif""></span></span><span lang="FA" style="font-family:"B Nazanin"">های ملی و بین­المللی از جمله</span><span dir="LTR" style="font-size:10.0pt">Google Scholar</span><span lang="FA" style="font-family:"B Nazanin"">، </span><span dir="LTR" style="font-size:10.0pt">Pubmed Ncbi</span><span lang="FA" style="font-family:"B Nazanin"">، </span><span dir="LTR" style="font-size:10.0pt">ResaerchGate</span><span lang="FA" style="font-family:"B Nazanin""> و پایگاه استنادی جهاد دانشگاهی طی سال­های 2012 تا 2024 انجام گرفته، نقش پلیفنلهای <a name="_Hlk140417535">اولئوروپین، کومارین، کوئرستین، رزوراترول، آپیژنین، کورکومین و نارینگین</a> در تعدیل مسیرهای سیگنالینگ سلولی مرتبط با سرطان معده مطالعه شده و نتایج مربوطه موردبررسی قرار گرفته </span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Calibri","sans-serif""></span></span><span lang="FA" style="font-family:"B Nazanin"">است.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:normal"><span style="tab-stops:right 468.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="font-family:"B Nazanin"">مطالعهها نشان دادند که ترکیبات فنلی موردنظر قادر به تأثیر بر مسیرهای پیامرسانیِ سلولی از جمله مسیرهای </span><span dir="LTR" style="font-size:10.0pt">PI3K</span><span lang="FA" style="font-family:"B Nazanin"">،</span> <span dir="LTR" style="font-size:10.0pt">Wnt/β</span><span lang="FA" style="font-family:"B Nazanin"">-کاتنین، </span><span dir="LTR" style="font-size:10.0pt">Hedgehog</span><span lang="FA" style="font-family:"B Nazanin"">، </span><span dir="LTR" style="font-size:10.0pt">Hippo</span><span lang="FA" style="font-family:"B Nazanin"">، </span><span dir="LTR" style="font-size:10.0pt">Notch</span><span lang="FA" style="font-family:"B Nazanin"">، فاکتور هسته­ای-</span><span dir="LTR" style="font-size:10.0pt">kB</span><span lang="FA" style="font-family:"B Nazanin""> گیرندههای فاکتور رشد اپیدرمی</span><span lang="FA" style="font-family:"B Nazanin""> و</span><span dir="LTR" style="font-size:10.0pt">MAPK </span><span style="font-family:"B Nazanin""> شده و تکثیر و مرگ سلولی را در جهت غلبه بر سلول سرطانی و افزایش بیانژنهای آپوپتوتیک موجب می­شوند. </span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:normal"><span style="tab-stops:right 468.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="font-family:"B Nazanin"">بنابراین با درنظر گرفتن خاصیت آنتیاکسیدانی، این ترکیبات می­توانند در کاهش استرس اکسیداتیو و آسیب سلولی مهم باشند.</span><b><span style="font-family:"B Nazanin"" lang="FA"></span></b></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:normal"><span style="tab-stops:center 234.0pt"><span style="font-family:"Times New Roman","serif""><span style="font-size:10.0pt">As one of the important sources of antioxidants, polyphenols play a significant role in biological interactions. Cancer, which is one of the most serious diseases involving human societies, and polyphenols have shown an effective role in inducing cell death and inhibiting cell proliferation <i>in vivo</i> and <i>in vitro</i> studies. Despite many efforts and the use of chemotherapy and radiotherapy methods, providing an efficient method for treating gastric cancer with a high success rate is the goal of many studies. </span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:normal"><span style="tab-stops:center 234.0pt"><span style="font-family:"Times New Roman","serif""><span style="font-size:10.0pt">In this study, which was conducted using first-hand sources available in national and international data banks such as Google Scholar, Pubmed NCBI, ResaerchGate, and the Academic Jihad Scientific Information</span><span style="font-size:10.0pt"><span style="background:white"> Center <em><span style="font-style:normal">database</span></em></span></span><span style="font-size:10.0pt"> during the years 2012 to 2024, the role of oleuropein, coumarin, and quercetin polyphenols, resveratrol, apigenin, curcumin and naringin have been studied in the modulation of cell signaling pathways related to gastric cancer and the relevant results have been analyzed. </span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:normal"><span style="tab-stops:center 234.0pt"><span style="font-family:"Times New Roman","serif""><span style="font-size:10.0pt">The studies showed that the desired phenolic compounds are able to affect cell signaling pathways, including PI3K, Wnt/β-catenin, Hedgehog, Hippo, Notch, nuclear factor-kB, epidermal growth factor receptors, MAPK pathways, proliferation, and cause cell death in order to overcome the cancer cells and increase the expression of apoptotic genes. Therefore, taking into account the antioxidant properties of these compounds, which can be important in reducing oxidative stress and cell damage.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:normal"><span style="tab-stops:center 234.0pt"><span style="font-family:"Times New Roman","serif""><span style="font-size:10.0pt"><span style="letter-spacing:-.2pt">Therefore, considering their antioxidant properties, these compounds could be important in reducing stress and cellular damage.</span></span></span></span></span></span><span style="font-size:12pt"><span style="line-height:normal"><span style="font-family:"Times New Roman","serif""><span dir="RTL" lang="AR-SA" style="font-family:"B Nazanin"">.</span><span style="font-size:10.0pt"></span></span></span></span><br>
سرطان معده, پلیفنل, آنتیاکسیدان, مسیرهای پیامرسانی سلولی
Gastric cancer, polyphenols, antioxidants, cellular signaling pathways.
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http://ncmbjpiau.ir/browse.php?a_code=A-10-2048-4&slc_lang=other&sid=1