New Cellularand Molecular Biotechnology Journal
مجله تازه هاي بيوتكنولوژي سلولي و مولكولي
NCMBJ
Basic Sciences
http://ncmbjpiau.ir
1
admin
2228-5458
2228-6926
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-
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8888
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fa
jalali
1390
5
1
gregorian
2011
8
1
1
3
online
1
fulltext
fa
میکرووزیکول های گلیوبلاستوما (غده گلیایی)، RNA و پروتئین هایی را انتقال می دهند که رشد تومور را توسعه داده و بیومارکرهای تشخیصی را فراهم می نمایند
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
سلولی و مولکولی
Cellular and molecular
گزارش کوتاه
Short Communication
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<!--stripped--><p style="text-align: justify" dir="rtl" class="BasicParagraph"><b><span lang="AR-YE">سابقه و
هدف:</span></b><span lang="AR-YE"> سلول های تومور گلیوبلاستوما میکرووزیکول های
(اکسوزوم های) محتوی </span><span dir="ltr">mRNA</span><span dir="rtl"></span><span lang="AR-YE"><span dir="rtl"></span> ،</span><span dir="ltr">miRNA</span><span dir="rtl"></span><span lang="AR-YE"><span dir="rtl"></span> و پروتئین های آنژیوژنیک را آزاد می کنند. این میکرووزیکول ها
بوسیله سلول های نرمال میزبان همچون سلول های اندوتلیال ریزرگی مغز (</span><span dir="ltr">brain</span><span dir="rtl"></span><span><span dir="rtl"></span> </span><span dir="ltr">microvascular</span><span dir="rtl"></span><span><span dir="rtl"></span> </span><span dir="ltr">endothelial</span><span dir="rtl"></span><span><span dir="rtl"></span> </span><span dir="ltr">cells</span><span dir="rtl"></span><span lang="AR-YE"><span dir="rtl"></span>) جذب می شوند.</span></p>
<p style="text-align: justify" dir="rtl" class="BasicParagraph"><b><span lang="AR-YE">مواد و
روش ها</span></b><span lang="AR-YE">: از طریق ترکیب یک </span><span dir="ltr">mRNA</span><span dir="rtl"></span><span lang="AR-YE"><span dir="rtl"></span> با یک پروتئین گزارش گر و
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میکرووزیکول ها بوسیله سلول های گیرنده ترجمه شده اند. این میکرووزیکول ها همچنین
غنی ازپروتئین
های رگ زایی می باشند و تشکیل توبول را از طریق سلول های اندوتلیال تحریک می کنند.</span><b><span lang="AR-YE"><br></span></b></p><p style="text-align: justify" dir="rtl" class="BasicParagraph"><b><span lang="AR-YE">یافته ها</span></b><span lang="AR-YE">:
میکرووزیکول های مشتق شده از تومور به عنوان وسیله تحویل دهنده اطلاعات ژنتیکی و
پروتئین ها به سلول های گیرنده در محیط توموری به کار می روند. میکرووزیکول های
گلیوبلاستوما همچنین تکثیر دودمان سلولی گلیومای انسان را تحریک می نمایند، که
نمایان کننده جنبه خودترقی دهنده آن ها است. </span><span dir="ltr">RNA</span><span lang="AR-YE">ی پیامبر
جهش یافته / متغیر و </span><span dir="ltr">miRNA</span><span dir="rtl"></span><span lang="AR-YE"><span dir="rtl"></span> اختصاصی گلیوماها را می توان در میکرووزیکول های سرم بیماران
مبتلا به گلیوبلاستوما تشخیص داد.</span></p>
<p style="text-align: justify" dir="rtl" class="BasicParagraph"><b><span lang="AR-YE">نتیجه
گیری</span></b><span lang="AR-YE">: </span><span dir="ltr">EGFRvIII</span><span dir="rtl"></span><span lang="AR-YE"><span dir="rtl"></span> مختص تومور (</span><span dir="ltr">tumor</span><span dir="rtl"></span><span lang="AR-YE"><span dir="rtl"></span>-</span><span dir="ltr">specific</span><span dir="rtl"></span><span lang="AR-YE"><span dir="rtl"></span>) در میکرووزیکول های 7 نفر از 25 بیمار مبتلا به گلیوبلاستوما
تشخیص داده شد. بنابراین میکرووزیکول های مشتق شده از تومور ممکن است اطلاعات
تشخیصی را فراهم کرده و به واسطه آزمایش خون به تصمیمات درمانی در مورد بیماران
سرطانی کمک نمایند.</span></p><span dir="ltr"></span> <br><p style="text-align: justify" dir="rtl" class="BasicParagraph"><span dir="ltr"> </span></p>
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</div><p style="direction: ltr unicode-bidi: embed font-family: times new roman,times,serif font-weight: bold text-align: justify" class="BasicParagraph"><font size="3"><span lang="NL" style="font-size: 14pt line-height: 120%">Aim and Background.</span><span lang="NL">
Glioblastoma tumour cells release microvesicles (exosomes) containing mRNA,
miRNA and angiogenic proteins. These microvesicles are taken up by normal host
cells, such as brain microvascular endothelial cells.</span></font></p><div style="font-weight: bold font-family: times new roman,times,serif text-align: justify"> </div><div style="font-weight: bold font-family: times new roman,times,serif text-align: justify"> </div><p style="direction: ltr unicode-bidi: embed font-family: times new roman,times,serif font-weight: bold text-align: justify" class="BasicParagraph"><font size="3"><span lang="NL"></span><span lang="NL" style="font-size: 14pt line-height: 120%">Materials and methods</span><span lang="NL">.</span><span lang="NL"> By incorporating an
mRNA for a reporter protein into these microvesicles, we demonstrate that
messages delivered by microvesicles are translated by recipient cells. These
microvesicles are also enriched in angiogenic proteins and stimulate tubule
formation by endothelial cells.</span></font></p><p style="direction: ltr unicode-bidi: embed font-family: times new roman,times,serif font-weight: bold text-align: justify" class="BasicParagraph"><font size="3"><span lang="NL"></span><span lang="NL" style="font-size: 14pt line-height: 120%">Results</span><span lang="NL">.</span><span lang="NL"> Tumour-derived microvesicles therefore
serve as a means of<span> </span>delivering genetic
information and proteins to recipient cells in the tumour environment.
Glioblastoma microvesicles also stimulated proliferation of a human glioma cell
line, indicating a self-promoting aspect. Messenger RNA mutant/variants and
miRNAs characteristic of gliomas could be detected in serum microvesicles of
glioblastoma patients. The tumour-specific EGFRvIII was detected in serum
microvesicles from 7 out of 25 glioblastoma patients.</span></font></p><div style="font-weight: bold font-family: times new roman,times,serif text-align: justify"> </div><p style="direction: ltr unicode-bidi: embed font-family: times new roman,times,serif font-weight: bold text-align: justify" class="BasicParagraph"><font size="3"><span lang="NL"></span><span lang="NL" style="font-size: 14pt line-height: 120%">Conclusion</span><span lang="NL">.</span><span lang="NL"> The tumour-specific EGFRvIII was detected
in serum microvesicles from 7 out of 25 glioblastoma patients. Thus,
tumour-derived microvesicles may provide diagnostic information and aid in
therapeutic decisions for cancer patients through a blood test.</span></font></p><div style="font-weight: bold font-family: times new roman,times,serif text-align: justify"> </div>
گلیوبلاستوما، miRNA ،EGFRvIII، میکرووزیکول
Glioblastoma, miRNA, EGFRvIII, microvesicle
75
88
http://ncmbjpiau.ir/browse.php?a_code=A-10-2-22&slc_lang=fa&sid=1
Hamid
Cheshmi
حمید
چشمی
hamid.ch65@gmail.com
1003194753284600583
1003194753284600583
Yes
Ferdowsi University of Mashhad
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