[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: ::
Back to the articles list Back to browse issues page
Investigating the survivine gene expression in DU145 prostate cancer cell line treated by Kombucha extract
Zahra Nayeb Shabani , Saeed Zaker Bostanabad , Masoud Salehipour
, saeedzaker20@yahoo.com
Abstract:   (236 Views)
Aim and Background:
Prostate cancer is the second common malignancy in men. In this study, the effect of Kombucha extract on DU145 prostate cancer cell line viability and expression of Survivine gene expression in cancer cells have been investigated
Material and methods:
Cell line was affected by extract of Kombucha and the amount of cell death through MTT and expression of Survivine gene expression by Real Time PCR were evaluated.                                    
Results:
The results showed that the cells treated with this extract significant had reduction in the number of cells after 48 hours and also had a decreasing effect on the expression of Survivine gene. These effects were dependent on the time and concentration of the treatment. The highest expression loss was observed at 75% concentration of extract in 72 hours after treatment.
Conclusion
Kombucha extract, by affecting the main genes in the pathway of apoptosis, reduces the amount of cell division, and this decrease leads to inhibit development of cancerous tissue.
Keywords: Prostate cancer, Kombucha, DU145
     
Type of Study: Research Article | Subject: Cellular and molecular
Received: 2018/10/13 | Accepted: 2018/10/13 | Published: 2018/10/13
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print



Back to the articles list Back to browse issues page
مجله تازه های بیوتکنولوژی سلولی - مولکولی New Cellular and Molecular Biotechnology Journal
Persian site map - English site map - Created in 0.06 seconds with 31 queries by YEKTAWEB 3781