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The Antioxidant and cytotoxic Effects of Lavandulla anguostifouliya on the 8305C cell line
Sedighe Mehdinezhad Doghikolayi , Mohsen Mohammadi
Department of Cell and Molecular Biology, College Biology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.
Abstract:   (143 Views)
Aim and Background:
Anaplastic thyroid cancer, including the most dangerous type of thyroid cancer.and as the most modern cancer treatments are ineffective with side effects, it seems essential to find impressive alternatives treatment. Lavender plant with the scientific name Lavandulla anguostifouliyaof familyLamiaceae, is a Perennial plant that has high nutritional and medicinal value. Therefore, the cytotoxic effect of ethanolic extract of Lavender plant on 8305C cell lines was evaluated.
 
Materials and methods:
In this study, for the first time, the cytotoxic effect of ethanolic extract of Aerial organsLavender plant on 8305c cell lines was evaluated. The Lavender plant in April 2016 of sehezare Tonekabon were collected andstudied; Then the antioxidant activity was evaluated by DPPH0 Assay. 8305C cell line was cultured in DMEM with 10% fetal bovine serum. Different concentrations of ethanolic extract of Lavender plant (5, 10, 20, 30, 40 and 50 mg/ml) for 24, 48 and 72 hours were applied on cancer cells 8305C. Then, the viability of cells using MTT assay was considered.
 
Results:
In this study, the free radical scavenging DPPH0 equals to 6/27mg/ml was calculated. The results of MTT assay showed that the ethanolic extract of Lavender plant has a cytotoxic effect on the 8305C cell line which is dependent to their doses. Also IC50 of the extract concentration for 8305C cells was obtained to be 5 mg/ml in time 48 hours.
 
Conclusion:
The ethanolic extract of Lavender plant which is dose-dependent could destroy the cancer cells and showed cytotoxic properties. Thus, this plant can be used as a medicinal plant against anaplastic thyroid cancer in wider scope.
Keywords: cancer, anaplastic thyroid, ethanolic extract, DPPH, MTT assay
     
Type of Study: Research Article | Subject: Cellular and molecular
Received: 2018/10/15 | Accepted: 2018/10/15 | Published: 2018/10/15
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مجله تازه های بیوتکنولوژی سلولی - مولکولی New Cellular and Molecular Biotechnology Journal
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