Volume 10, Issue 37 (12-2019)
NCMBJ 2019, 10(37): 77-88 |
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Yaran R, Rastegari A A, Moshtaghi A A. Biochemical study of type 2 diabetes mellitus with changes in serum levels of, zinc , copper, magnesium and chromium (Zn,CU,Mg,Cr) in human population of Isfahan province. NCMBJ 2019; 10 (37) :77-88
URL: http://ncmbjpiau.ir/article-1-1249-en.html
URL: http://ncmbjpiau.ir/article-1-1249-en.html
Department of Molecular and Cell Biochemistry, Faculty of Biological Sciences, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
Abstract: (3782 Views)
Aim and Background:Diabetes is a metabolic disease that is caused by a chronic increase in blood sugar due to a defect in insulin secretion or function. This study demonstrates the relationship between serum zinc, copper, magnesium and chromium trace elements in the patient population.
Materials and Methods:In this study, subjects were randomly selected in three groups, including 50 females, 50 males and 100 controls. Data were collected through interviews and questionnaires. Serum trace elements in the blood of fasting patients were evaluated using atomic absorption spectrometry, direct calorimetry and photometry.
Results:Evidence from this study indicates that the mean serum zinc and copper concentrations in diabetic compared to non-diabetic patients were significantly decreased (P <0.001) and (P = 0.025). On the other hand, serum concentrations of chromium and magnesium in diabetic and non-diabetic subjects were not significantly different. Linear regression analysis of gender was not statistically significant and the decrease in serum zinc and copper concentrations was independent of individual gender.
Conclusion:Evaluation of serum concentration of trace elements shows that the concentration of two elements of zinc and copper in diabetes is significant and can be an appropriate marker for the probability of diabetes. Decreased zinc levels and unchanged levels of chromium and magnesium in diabetic serum should be sought for other factors such as individual conditions, urinary incontinence and Interventional factors that require further study.
Materials and Methods:In this study, subjects were randomly selected in three groups, including 50 females, 50 males and 100 controls. Data were collected through interviews and questionnaires. Serum trace elements in the blood of fasting patients were evaluated using atomic absorption spectrometry, direct calorimetry and photometry.
Results:Evidence from this study indicates that the mean serum zinc and copper concentrations in diabetic compared to non-diabetic patients were significantly decreased (P <0.001) and (P = 0.025). On the other hand, serum concentrations of chromium and magnesium in diabetic and non-diabetic subjects were not significantly different. Linear regression analysis of gender was not statistically significant and the decrease in serum zinc and copper concentrations was independent of individual gender.
Conclusion:Evaluation of serum concentration of trace elements shows that the concentration of two elements of zinc and copper in diabetes is significant and can be an appropriate marker for the probability of diabetes. Decreased zinc levels and unchanged levels of chromium and magnesium in diabetic serum should be sought for other factors such as individual conditions, urinary incontinence and Interventional factors that require further study.
Type of Study: Research Article |
Subject:
Cellular and molecular
Received: 2019/12/5 | Accepted: 2019/12/5 | Published: 2019/12/5
Received: 2019/12/5 | Accepted: 2019/12/5 | Published: 2019/12/5
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