Volume 14, Issue 55 (6-2024)
NCMBJ 2024, 14(55): 9-18 |
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Ahmadi N, Zakerbostanabadi S, Khaki A A, Khodarahmi P, Baharara J. Effects of anthocyanins on blood biochemical factors related to
diabetes in diabetic adult rats treated with streptococci. NCMBJ 2024; 14 (55) :9-18
URL: http://ncmbjpiau.ir/article-1-1672-en.html
URL: http://ncmbjpiau.ir/article-1-1672-en.html
Department of Biology, Islamic Azad University, Prand Branch, Parand, Iran , saeedzaker20@yahoo.com
Abstract: (708 Views)
Aim and Background: Diabetes Mellitus is related to biochemical and physiological changes in the body. In this study, the effects of anthocyanin on blood biochemical factors related to diabetes in adult diabetic rats treated with streptococci were investigated.
Material and methods: In this study, 32 male Wistar rats were used, which were divided into four groups as follows: a) control group b) diabetic control group that received normal saline as a solvent c) group of rats Diabetics treated with 100 mg/kg of anthocyanin d) group of healthy rats that received 100 mg/kg of anthocyanin. To induce diabetes in the experimental groups, a single dose of 50 mg/kg streptozotocin (STZ) (Sigma) dissolved in 5 mm citrate buffer (pH = 4.5) was injected intraperitoneally. Then, fasting blood sugar, insulin serum level, and lipid profile serum level were measured.
Results: fasting blood sugar and serum levels of TG and cholesterol increased significantly in the diabetic control group compared to the control group (p<0.05). Also, fasting blood sugar levels and serum TG and cholesterol levels in the groups treated with anthocyanin showed a significant decrease in comparison with the diabetic control group (P < 0.05). In all diabetic groups compared to the control group, the level of HDL and serum insulin decreased significantly (P < 0.05), and in the groups treated with anthocyanin compared to the diabetic control group, the level of HDL and serum insulin increased. Also, the weight of rats in the diabetic control group decreased significantly, and in the treatment groups with anthocyanin, the weight of the rats increased compared to the diabetic control group (p<0.05).
Conclusion: Anthocyanin can be effective on fasting blood sugar, serum level of insulin, serum level of fat profile and prevent biochemical damage caused by diabetes in diabetic rats treated with streptozocin.
Material and methods: In this study, 32 male Wistar rats were used, which were divided into four groups as follows: a) control group b) diabetic control group that received normal saline as a solvent c) group of rats Diabetics treated with 100 mg/kg of anthocyanin d) group of healthy rats that received 100 mg/kg of anthocyanin. To induce diabetes in the experimental groups, a single dose of 50 mg/kg streptozotocin (STZ) (Sigma) dissolved in 5 mm citrate buffer (pH = 4.5) was injected intraperitoneally. Then, fasting blood sugar, insulin serum level, and lipid profile serum level were measured.
Results: fasting blood sugar and serum levels of TG and cholesterol increased significantly in the diabetic control group compared to the control group (p<0.05). Also, fasting blood sugar levels and serum TG and cholesterol levels in the groups treated with anthocyanin showed a significant decrease in comparison with the diabetic control group (P < 0.05). In all diabetic groups compared to the control group, the level of HDL and serum insulin decreased significantly (P < 0.05), and in the groups treated with anthocyanin compared to the diabetic control group, the level of HDL and serum insulin increased. Also, the weight of rats in the diabetic control group decreased significantly, and in the treatment groups with anthocyanin, the weight of the rats increased compared to the diabetic control group (p<0.05).
Conclusion: Anthocyanin can be effective on fasting blood sugar, serum level of insulin, serum level of fat profile and prevent biochemical damage caused by diabetes in diabetic rats treated with streptozocin.
Type of Study: Research Article |
Subject:
Physiology
Received: 2024/07/8 | Accepted: 2024/06/30 | Published: 2024/06/30
Received: 2024/07/8 | Accepted: 2024/06/30 | Published: 2024/06/30
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