Volume 15, Issue 59 (7-2025)
NCMBJ 2025, 15(59): 1-17 |
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alimohamadi G, Rajabvand N, Nasiri R, Zaefizadeh M, Ochi Ardabili1 M. The Role of Polyphenols in Modulating Cell Signaling Pathways in Gastric Cancer-Related Cell Lines. NCMBJ 2025; 15 (59) :1-17
URL: http://ncmbjpiau.ir/article-1-1764-en.html
URL: http://ncmbjpiau.ir/article-1-1764-en.html
Cultivation and Development Research Department, Medicinal Plants Research Center, Medicinal Plants Research Institute, ACECR, Karaj, Iran. , ochi@acecr.ac.ir
Abstract: (31 Views)
As one of the important sources of antioxidants, polyphenols play a significant role in biological interactions. Cancer, which is one of the most serious diseases involving human societies, and polyphenols have shown an effective role in inducing cell death and inhibiting cell proliferation in vivo and in vitro studies. Despite many efforts and the use of chemotherapy and radiotherapy methods, providing an efficient method for treating gastric cancer with a high success rate is the goal of many studies.
In this study, which was conducted using first-hand sources available in national and international data banks such as Google Scholar, Pubmed NCBI, ResaerchGate, and the Academic Jihad Scientific Information Center database during the years 2012 to 2024, the role of oleuropein, coumarin, and quercetin polyphenols, resveratrol, apigenin, curcumin and naringin have been studied in the modulation of cell signaling pathways related to gastric cancer and the relevant results have been analyzed.
The studies showed that the desired phenolic compounds are able to affect cell signaling pathways, including PI3K, Wnt/β-catenin, Hedgehog, Hippo, Notch, nuclear factor-kB, epidermal growth factor receptors, MAPK pathways, proliferation, and cause cell death in order to overcome the cancer cells and increase the expression of apoptotic genes. Therefore, taking into account the antioxidant properties of these compounds, which can be important in reducing oxidative stress and cell damage.
Therefore, considering their antioxidant properties, these compounds could be important in reducing stress and cellular damage.
In this study, which was conducted using first-hand sources available in national and international data banks such as Google Scholar, Pubmed NCBI, ResaerchGate, and the Academic Jihad Scientific Information Center database during the years 2012 to 2024, the role of oleuropein, coumarin, and quercetin polyphenols, resveratrol, apigenin, curcumin and naringin have been studied in the modulation of cell signaling pathways related to gastric cancer and the relevant results have been analyzed.
The studies showed that the desired phenolic compounds are able to affect cell signaling pathways, including PI3K, Wnt/β-catenin, Hedgehog, Hippo, Notch, nuclear factor-kB, epidermal growth factor receptors, MAPK pathways, proliferation, and cause cell death in order to overcome the cancer cells and increase the expression of apoptotic genes. Therefore, taking into account the antioxidant properties of these compounds, which can be important in reducing oxidative stress and cell damage.
Therefore, considering their antioxidant properties, these compounds could be important in reducing stress and cellular damage.
Type of Study: Review Article |
Subject:
Cellular and molecular
Received: 2025/08/27 | Accepted: 2025/07/1 | Published: 2025/07/1
Received: 2025/08/27 | Accepted: 2025/07/1 | Published: 2025/07/1
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