Aim and background: Epidemiological and animal experimental studies indicated that flavonoid rich diets could affected positively on decrease of the prevalence of neuronal degenerations e.g Alzheimer and Parkinsonism diseases. In basis of the positive function of crataegus extract on decrease of oxidative factors and other helpful chararacteristics of this extract, the present research examined crataegus extract effect on passive avoidance learning of male wistar rat.

Materials and Methods: 24 rats with 250-300 gram weight have been divided to three main groups: 1-control (intact) 2- sham (solvent receivers) 3-Crataegus extract. This extract has been administered daily (100mg/kg) for two weeks by gavages' method. Passive avoidance learning test were achieved by shuttle box system. One day after acquisition retrieval test has been done. For this, animal was putted to light compartment and after 30 seconds guillotine door was opened and the time that was consumed for entering to dark component was recorded. Data were analyzed by SPSS software with one way ANOVA and Tuckey test.

Results: were indicated no difference between intact and sham groups for time of entering to dark component but there was significant increase between extract and intact groups (P<0.001) and decrease between them for entering to dark component (P<0.001)

Conclusion: Results of this study showed that treatment by Crataegus extract that is flavonoid rich, has been resulted to recovery of learning and memory.