Volume 5, Issue 18 (4-2015)
NCMBJ 2015, 5(18): 29-34 |
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Erfani M, Shirmardi S P. The synthesis of labeled colchicine and the study of its biological distribution . NCMBJ 2015; 5 (18) :29-34
URL: http://ncmbjpiau.ir/article-1-627-en.html
URL: http://ncmbjpiau.ir/article-1-627-en.html
Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), P.O.Box: 14395-836, Tehran, Iran , mgandomkar@aeoi.org.ir
Abstract: (8773 Views)
Aim and Background:
Colchicine alkaloid is originally extracted from plants of the Colchicum automnale L. due to its anti- mitotic effects in the treatment of gout and Mediterranean fever.
Materials and Methods: Colchicine has been labeled by HYNIC (hydrazino nicotinic acid) chelator to 99mTc. After labeling by HYNIC-99mTc, it is injected via intravenous route to mice and the biodistribution of this radiopharmaceutical is investigated.
Results: The results showed a significant efficiency for the combination. It is seen a relatively rapid removal of compound from the blood with a rapid accumulation in kidney and liver. This compound accumulates in the liver and secreted into the intestine immediately so it is observed in the small and large intestines. These organs were identified as the target organs.
Conclusion: According to the results, this labeled compound can be used as an agent to study the function and response to therapy by Colchicine especially in the organs which have no secretive accumulation.
Materials and Methods: Colchicine has been labeled by HYNIC (hydrazino nicotinic acid) chelator to 99mTc. After labeling by HYNIC-99mTc, it is injected via intravenous route to mice and the biodistribution of this radiopharmaceutical is investigated.
Results: The results showed a significant efficiency for the combination. It is seen a relatively rapid removal of compound from the blood with a rapid accumulation in kidney and liver. This compound accumulates in the liver and secreted into the intestine immediately so it is observed in the small and large intestines. These organs were identified as the target organs.
Conclusion: According to the results, this labeled compound can be used as an agent to study the function and response to therapy by Colchicine especially in the organs which have no secretive accumulation.
Type of Study: Research Article |
Subject:
Cellular and molecular
Received: 2015/05/31 | Accepted: 2015/05/31 | Published: 2015/05/31
Received: 2015/05/31 | Accepted: 2015/05/31 | Published: 2015/05/31
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