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Aim and Background: Lincomycin is one of the licozamid compounds. The aim of this study is optimization of lincomycin production using one-factor-at-a-time-method and antimicrobial activity of this antibiotic by Streptomyces lincolenesis PTCC 1629 Material and methods: At first different inorganic and organic carbon and nitrogen sources such as glucose, sucrose, lactose, maltose, fructose, potassium nitrate, sodium nitrate, ammonium sulfate, KH2PO4, CaCl2, CaCo3 were optimized for lincomycin production using one-factor-at-a-time method. Then antimicrobial activity assessed on refrence strains. Results: The results showed that glucose, potassium nitrate were the best carbon and nitrogen sources for lincomycin production by Streptomyces lincolenesis PTCC 1629. Also, the obtained results showed that gram positive strains were sensitive to lincomycin produced by this strain, but gram negative strains were resistant. Conclusion: The obtained results showed that glucose in preculture and production media was the best carbon source for lincomycin production. The best pH and temperature for lincomycin production were 2/7- 8/6 and 30-28°C, respectively.

Keywords: Optimization, Streptomyces lincolenesis PTCC 1629, one-factor-at-time- methd, lincomycin

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