Volume 9, Issue 36 (9-2019)                   NCMBJ 2019, 9(36): 43-52 | Back to browse issues page

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Zamani Dehkordi N, Zia Jahromi N, Sazgar H. Comparison and comparison of CD133 gene expression in healthy individuals and people with leukemia. NCMBJ. 2019; 9 (36) :43-52
URL: http://ncmbjpiau.ir/article-1-1220-en.html
Department of Biology, Science Faculty, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
Abstract:   (2035 Views)
Aim & Background: CD133 is a membrane glycoprotein that contains 865 amino acids and is normally expressed in hematopoietic stem cells, endothelial precursor cells, neuronal and glial stem cells. The CD133 marker has been used to identify cancer cells and many malignancies, including the brain, colon and lung. The aim of this study was to evaluate the expression level of CD133 as a marker for the detection of leukemia.
Materials and Methods: Blood samples were collected from 30 patients with leukemia and 30 healthy controls. After RNA extraction, cDNA was synthesized and CD133 gene expression was evaluated using Real-Time PCR technique. Data were analyzed using SPSS 16.0 software.
Results: According to the obtained data and statistical analysis (p <0.05) using SPSS software, the expression level of CD133 gene in cancerous samples was significantly increased compared to healthy ones. That (p CD133 = 0.0065) was obtained.
Discussion and Conclusion: Given the role of CD133 as a marker for the identification of many cancers, it can be concluded that CD133 can be a good marker for cancer detection and prevention. Be leukemia
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Type of Study: Research Article | Subject: Cellular and molecular
Received: 2019/08/27 | Accepted: 2019/08/27 | Published: 2019/08/27

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