Volume 9, Issue 34 (4-2019)                   NCMBJ 2019, 9(34): 37-46 | Back to browse issues page

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kangavari S, shaheli M, rezaeian A. Role of class 1 Integron in prevalence extended-spectrum beta-lactamases of class D (oxa-2 , oxa-10) along with determining antibiotic resistance pattern in Pseudomonas strains isolated from clinical specimens. NCMBJ 2019; 9 (34) :37-46
URL: http://ncmbjpiau.ir/article-1-1180-en.html
Department of Microbiology, Jahrom Branch, Islamic Azad University, Jahrom, Iran
Abstract:   (3556 Views)
Aim and Background:Eradicating infections is difficult due to the presence of genes on the introns, especially the beta-lactamase enzymes and  The importance of their resistance is high.The purpose of this study was to determine the beta-lactamase genes (OXA-2 , OXA-10) , Integron class 1  and antibiotic resistance.
Material and methods:In this cross sectional descriptive study, 120 Pseudomonas isolates were collected from Shiraz Burn Hospital during summer of 1395. After confirmation by biochemical tests, The presence of beta-lactamase genes was evaluated by using antibiotic discs and PCR method.
Results :78.5% of the isolates had OXA-10 gene, 77.57% of the OXA-2 gene, 34.58% containing Int1, and 95.38% of the samples were MDR.Maximum resistant was seen in cefepime(79.43%) and the minimum was for to tobramycin(10.28%).
Conclusion :Class1 integron, 2-oxa and 10-oxa beta-lactamase genes, did not show up a meaningful relationship at the same time.the production of beta-lactamase enhances the increasing resistance and their frequency is increasing according to the results of other studies. This will lead more control over the prescription and use of antibiotics.
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Type of Study: Research Article | Subject: Cellular and molecular
Received: 2019/03/16 | Accepted: 2019/03/16 | Published: 2019/03/16

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