Volume 13, Issue 52 (9-2023)
NCMBJ 2023, 13(52): 23-32 |
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Jaberi M, Asadi E. Relationship between serum leptin and insulin resistance among obese Iranian women. NCMBJ 2023; 13 (52) :23-32
URL: http://ncmbjpiau.ir/article-1-1582-en.html
URL: http://ncmbjpiau.ir/article-1-1582-en.html
Department of Biolgy, Islamshahr Branch , Islamic Azad University, Islamshahr, Iran
Abstract: (4878 Views)
Aim and Background
The process of obesity is complex and many factors, including two key hormones, leptin and insulin are involved. The homeostatic role of insulin in energy stability is reduced by insulin resistance. It is possible that leptin and insulin have a regulatory role on each other, therefore, the present study investigated the relationship between BMI, leptin , insulin and insulin resistance.
Materials and methods
In this cross-sectional study, 140 women were examined in 2 equal groups with normal (18.5-24.9) or obese (≥ 30) BMI. After fasting for 10-12 hours, 10 cc of venous blood was taken from the subjects, Blood sugar was measured by glucose oxidase, insulin and leptin by ELISA method, and HOMA-IR index was calculated. The data were expressed as mean ± standard deviation. P < 0.05 was considered statistically significant.
Results: There was a significant difference between the groups in terms of leptin level, and there was a significant correlation between BMI and plasma leptin level of the studied subjects, r=0.07 and P<0.01. Also, there was a significant relationship between serum leptin and fasting insulin (r = 0.05 and P < 0.01. In terms of the HOMA-IR, a significant difference between the groups was observed which was higher in obese than in normal.
Conclusion
BMI is the main factor in regulating leptin levels. Probably the continuity of insulin and leptin levels is due to the determining role of BMI on both of them.
The process of obesity is complex and many factors, including two key hormones, leptin and insulin are involved. The homeostatic role of insulin in energy stability is reduced by insulin resistance. It is possible that leptin and insulin have a regulatory role on each other, therefore, the present study investigated the relationship between BMI, leptin , insulin and insulin resistance.
Materials and methods
In this cross-sectional study, 140 women were examined in 2 equal groups with normal (18.5-24.9) or obese (≥ 30) BMI. After fasting for 10-12 hours, 10 cc of venous blood was taken from the subjects, Blood sugar was measured by glucose oxidase, insulin and leptin by ELISA method, and HOMA-IR index was calculated. The data were expressed as mean ± standard deviation. P < 0.05 was considered statistically significant.
Results: There was a significant difference between the groups in terms of leptin level, and there was a significant correlation between BMI and plasma leptin level of the studied subjects, r=0.07 and P<0.01. Also, there was a significant relationship between serum leptin and fasting insulin (r = 0.05 and P < 0.01. In terms of the HOMA-IR, a significant difference between the groups was observed which was higher in obese than in normal.
Conclusion
BMI is the main factor in regulating leptin levels. Probably the continuity of insulin and leptin levels is due to the determining role of BMI on both of them.
Type of Study: Research Article |
Subject:
Physiology
Received: 2023/03/14 | Accepted: 2023/09/23 | Published: 2023/10/21
Received: 2023/03/14 | Accepted: 2023/09/23 | Published: 2023/10/21
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