Volume 15, Issue 60 (12-2025)
NCMBJ 2025, 15(60): 27-40 |
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Tavakoli Yaraki A, Arian S, Houshani M. The Evaluation of Antioxidant Compounds and Antibacterial of Leaf, Flower, and Root Extracts of Sambucus ebulus and their Toxicity on Lung Cancer Cells. NCMBJ 2025; 15 (60) :27-40
URL: http://ncmbjpiau.ir/article-1-1783-en.html
URL: http://ncmbjpiau.ir/article-1-1783-en.html
Assistant Professor, Department of Microbiology, To.C., Islamic Azad University,Tonekabon, Iran. , Simin.aryan@yahoo.com
Abstract: (23 Views)
Abstract
Aim and Background: Cancer is considered one of the leading causes of mortality worldwide. Components derived from natural plants that induce apoptosis are used for cancer treatment. Also, with the increasing resistance of bacteria to antibiotics and their side effects, the use of medicinal plants in the treatment of bacterial infections is increasing. Therefore, this study aims to evaluate the antioxidant and antibacterial properties of the leaves, flowers, and roots extract of Sambucus ebulus and their inhibitory effect on lung cancer cells.
Materials and Methods: Different parts of the S. ebulus were collected from Abbas Abad city and extracted by the maceration method. To determine the cytotoxicity of the extracts, the MTT method was used, and the antimicrobial activity of the extracts was determined by disk diffusion methods. Also, total phenol, flavonoid, and anthocyanin contents were measured.
Results: The results showed that the highest content of total phenol was obtained from the leaf extract. The effect of the extracts on cell growth inhibition was concentration and time-dependent; the highest percentage of cell growth inhibition at the concentration of 4000 μg/mL in leaf and flower extracts was 97.47% and 97.87%, respectively, in the duration of 72 hours. Also, the maximum inhibitory effect of leaf and flower extracts on Gram-positive bacteria, Staphylococcus aureus, was obtained at a concentration of 1000 mg/mL.
Aim and Background: Cancer is considered one of the leading causes of mortality worldwide. Components derived from natural plants that induce apoptosis are used for cancer treatment. Also, with the increasing resistance of bacteria to antibiotics and their side effects, the use of medicinal plants in the treatment of bacterial infections is increasing. Therefore, this study aims to evaluate the antioxidant and antibacterial properties of the leaves, flowers, and roots extract of Sambucus ebulus and their inhibitory effect on lung cancer cells.
Materials and Methods: Different parts of the S. ebulus were collected from Abbas Abad city and extracted by the maceration method. To determine the cytotoxicity of the extracts, the MTT method was used, and the antimicrobial activity of the extracts was determined by disk diffusion methods. Also, total phenol, flavonoid, and anthocyanin contents were measured.
Results: The results showed that the highest content of total phenol was obtained from the leaf extract. The effect of the extracts on cell growth inhibition was concentration and time-dependent; the highest percentage of cell growth inhibition at the concentration of 4000 μg/mL in leaf and flower extracts was 97.47% and 97.87%, respectively, in the duration of 72 hours. Also, the maximum inhibitory effect of leaf and flower extracts on Gram-positive bacteria, Staphylococcus aureus, was obtained at a concentration of 1000 mg/mL.
Conclusion: The results of this study suggest that especially the leaf and flower extract of S. ebulus plant can be an accessible source of antioxidant compounds and can be used as a medicinal plant against lung cancer, subject to extensive research due to its high anti-cancer properties.
Type of Study: Research Article |
Subject:
Cellular and molecular
Received: 2025/12/16 | Accepted: 2025/12/1 | Published: 2025/12/1
Received: 2025/12/16 | Accepted: 2025/12/1 | Published: 2025/12/1
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