Volume 7, Issue 27 (9-2017)                   NCMBJ 2017, 7(27): 77-84 | Back to browse issues page

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Naderinezhad S, Haghirosadat F, Amoabediny G, Naderinezhad A, Esmaili Z, Akbarzade A. Synthesis of biodegradable and self-assembled anionic nano –carrier: Novel approach for improvement of Curcumin- delivery to bone tumors cells & Mathematical modeling of drug-release kinetic. NCMBJ 2017; 7 (27) :77-84
URL: http://ncmbjpiau.ir/article-1-1004-en.html
Synthesis of biodegradable and self-assembled anionic nano –carrier: Novel approach for improvement of Curcumin- delivery to bone tumors cells & Mathematical modeling of drug-release kinetic
Samira Naderinezhad , Fateme Haghirosadat , Ghasem Amoabediny , Ali Naderinezhad , Zahra Esmaili , Azim Akbarzade
1- Department of Biotechnology and Pharmaceutical Engineering, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran. , amoabedini@ut.ac.ir
Abstract:   (6615 Views)
Aim and Background: Osteosarcoma is the most common cancer among adolescents. Curcumin has induction sensitivity effect to cancer cells against chemotherapy and anti-tumor. In present study, the sustained- release niosomal carrier containing Curcumin were prepared to improve anti-cancer effect of Curcumin against osteosarcoma. Material and methods: Anionic prepared niosomal vesicle are contained 70 % (molar ratio) of Tween 60, 30% (molar ratio) of Cholesterol in the presence DSPE-mPEG 200. Prepared nano-particle was characterized and the cytotoxicity of free Curcumin was evaluated in comparing of niosomal Curcumin on MG-63 cell line using MTT assay. A suitable kinetic model was also suggested in order to predicting drug release. Results: Results showed the size diameter, encapsulation efficiency, zeta potential and poly disparity index are 242 nm, 95.2%, -38 mv and 0.17, respectively. Prepared niosomal particles are controlled-release and the cumulative release is 43.87 % during 96 hours. Peppa’s model indicates good confirmation with experimental results. Cytotoxicity results showed 0.9-fols improvement in killing cells efficiency for niosomal Curcumin in comparing free Curcumin. Conclusion: The niosomal carrier containing Curcumin is sustained-release, mono-disperse with high encapsulation efficiency and suitable size diameter. The results of surface charge evaluation confirmed that prepared nano-carrier is anionic and it can effectively be used in the treatment of bone cancer.
Keywords: Niosome, mathematical modeling of drug release kinetic, Curcumin, hydrophobic, characterization, osteosarcoma.
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Type of Study: Research Article | Subject: Genetics
Received: 2017/10/24 | Accepted: 2017/10/24 | Published: 2017/10/24
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