Volume 7, Issue 28 (10-2017)
NCMBJ 2017, 7(28): 19-24 |
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Oji F, Yaghoubi H. The Association Study between D/I Polymorphism of Angiotensin-Converting Enzyme (ACE) Gene with Obesity in the Population of Ardabil Province. NCMBJ 2017; 7 (28) :19-24
URL: http://ncmbjpiau.ir/article-1-1028-en.html
URL: http://ncmbjpiau.ir/article-1-1028-en.html
Department of Biology, Ardabil Branch, Islamic Azad University, Ardabil, Iran , yaghoubi_h@iauardabil.ac.ir
Abstract: (5157 Views)
Aim and Background:
Today many genes have been reported that affect obesity in complex ways. One of these genes is the polymorphism of ACE gene. Angiotensin converting enzyme (ACE) is an important factor that can affect adipose tissue metabolism. The aim of this study was to investigate the relationship between ACE gene polymorphism and obesity in the population of Ardabil province.
Methods and materials:
The 172 people attending this study were divided into two individuals of BMI < 30 and BMI≥ 30 according to their body mass index. The DNAs of the sample were extracted using the saturated salt method and the extracted strains from normal and obsess participants were compared with each other under electrophoresis by PCR.
Results:
In the group by BMI<30 there were 57.5% male and 42.5% female participants. By contrast, in the group by BMI≥30, there were 42% male and 58% female participants. The average age of the participants in BMI<30 group was 47.55 years but in the BMI≥30 group it was 52.45 years. BMI mean of the people in BMI<30 was 25.19 and BMI mean of the people in BMI≥30 was 32.58. DD genotype frequency in BMI≥30 was 0.83 which is more than the frequency of BMI<30 (0.83 against 0.71).
Conclusion:
The obtained results of this research suggested that genotype DD in ACE gene has a relationship with the obesity of Ardabil province population.
Today many genes have been reported that affect obesity in complex ways. One of these genes is the polymorphism of ACE gene. Angiotensin converting enzyme (ACE) is an important factor that can affect adipose tissue metabolism. The aim of this study was to investigate the relationship between ACE gene polymorphism and obesity in the population of Ardabil province.
Methods and materials:
The 172 people attending this study were divided into two individuals of BMI < 30 and BMI≥ 30 according to their body mass index. The DNAs of the sample were extracted using the saturated salt method and the extracted strains from normal and obsess participants were compared with each other under electrophoresis by PCR.
Results:
In the group by BMI<30 there were 57.5% male and 42.5% female participants. By contrast, in the group by BMI≥30, there were 42% male and 58% female participants. The average age of the participants in BMI<30 group was 47.55 years but in the BMI≥30 group it was 52.45 years. BMI mean of the people in BMI<30 was 25.19 and BMI mean of the people in BMI≥30 was 32.58. DD genotype frequency in BMI≥30 was 0.83 which is more than the frequency of BMI<30 (0.83 against 0.71).
Conclusion:
The obtained results of this research suggested that genotype DD in ACE gene has a relationship with the obesity of Ardabil province population.
Type of Study: Research Article |
Subject:
Genetics
Received: 2017/12/30 | Accepted: 2017/12/30 | Published: 2017/12/30
Received: 2017/12/30 | Accepted: 2017/12/30 | Published: 2017/12/30
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