Volume 1, Issue 2 (4-2011)                   NCMBJ 2011, 1(2): 7-15 | Back to browse issues page

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Shekarabei M, Mohammadi Kanisavaran A. Development and function of B-1 cells. NCMBJ. 2011; 1 (2) :7-15
URL: http://ncmbjpiau.ir/article-1-17-en.html
Tehran Medical University, Medical Faculty, Immunology Department
Abstract:   (21965 Views)

B-1 cells comprise a small percentage of the B lymphocytes that reside in multiple tissues including theperitoneal and pleural cavities. Functionally, B-1 cells participate in innate immunity by producing the majority of the natural IgM in serum, which protects against invading pathogens before the onset of the adaptive immune response. B-1 cells arise from fetal and neonatal progenitors and are distinct from the adult bone marrow progenitors that give rise to follicular and marginal zone B-2 cells. Recent studies have attempted to delineate the progenitors of B-1 cells from those of B-2 cells. Experimental  data from studies supporting the hypothesis that B-1 cells belong to a developmental lineage distinct from B-2 cells, and draws attention to recent studies that have defined new roles for the B-1 a and B-1 b cell subsets in the response to bacteria and self-antigens.


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Type of Study: Review Article | Subject: Immonology
Received: 2011/05/4 | Accepted: 2014/04/23 | Published: 2014/04/23

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