Volume 2, Issue 7 (9-2012)                   NCMBJ 2012, 2(7): 91-96 | Back to browse issues page

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Bozorgnejad A, Baghi F, Zamanpour niavaran A, Akbarzadeh A, Arjmand M. Nanocarrier Liposome Production from Lecithin and Cisplatin Loading on it. NCMBJ. 2012; 2 (7) :91-96
URL: http://ncmbjpiau.ir/article-1-213-en.html
1. chemical engineering , Department of chemical engineering, science and research branch, Islamic Azad University, Tehran- Iran , Fatemehbaghi63@gmail.com
Abstract:   (22786 Views)

Aim and Background. The main purpose of this research is cisplatin loading on liposome for targeted drug delivery. The suitable loading percentage obtained showed that we have achieved the target.

Material and Methods. Liposome was extracted from a lecithin source and after dissolving in phosphate buffer the solution was sonicated in bath sonicator for loading the cisplatin on extracted liposomes and resizing to nano scale.

Results. Total amount of plating in sonicated solution is known. Platin which exists in solution transparent phase after ultra centrifuge process, was determined with atomic absorption test. By subtracting these two amounts from each other we achieved the amount of platin existed in sedimentation phase. Particles’ size in nano scale were confirmed with zeta sizer.

Conclusion. Liposome is known as a new lipid carrier for targeted drug delivery in cancer therapy. The anti cancer drug “cisplatin”, was encapsulated in liposome to reduce the side effects of drug on other cells and have a more dosage of drug on target cell.

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Type of Study: Research Article | Subject: Biochemistry
Received: 2012/09/15 | Published: 2012/09/15

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