Volume 1, Issue 3 (8-2011)                   NCMBJ 2011, 1(3): 7-15 | Back to browse issues page

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Mohajeri N, kazemi B. Innate Immunity activated via siRNA. NCMBJ. 2011; 1 (3) :7-15
URL: http://ncmbjpiau.ir/article-1-40-en.html
Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Science , bahram_14@yahoo.com
Abstract:   (23968 Views)
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Aim and Background .RNA interference has the role of gene silencing process that is triggered by double-stranded RNAs. Common to all cell types, is the production of 21-24 nucleotide small interfering RNA (siRNA), which guides the RNA-induced silencing complex (RISC) to identify and cleave target mRNA sequences. siRNA duplex are potent activators of innate immune system that induce high levels of cytokines and interferon. Toll-like receptors trigger the first line of innate immune response that is mediated by transcriptional induction of a large number of cellular genes. siRNA interact with cytoplasmic RNA sensors such as: Retinoic - acid Inducible Gene -I (RIG-I), RNA-Activated protein kinase R(PKR), Interferon Regulatory Factor (IRF) and 2'-5' oligo adenylate synthetase (2'-5'OAS), Nuclear Factor kappa B cell(NF-κB). siRNA modification are on the sugar, phosphate linkage, base, overhangs and termini nucleotides leading to increase half-life siRNA. This review article describes gene silencing and innate immune caused by siRNA.

 

 
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Type of Study: Review Article | Subject: Immonology
Received: 2011/08/11 | Published: 2011/08/15

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