Mendeley  

Zotero  

ghorbani ranjbary A, ghorbani ranjbary N, ghorbani ranjbary Z, ghorbani ranjbary S. Study of nettle hydro alcoholic extraction (Urtica dioica) influence on spermatogenesis and Testosterone, spermatogenesis hormones, changes in rats. NCMBJ 2014; 4 (14) :31-39
URL: http://ncmbjpiau.ir/article-1-517-en.html

Materials and Methods :40 male adult rats by the weights of almost 195±5 g were divided into 5 groups each containing eight members. Rats of experimental group received 25, 50, 75 mk value of nettle extraction interior peritoneal in 28 days, respectively. The evidence group just received the soluble form of drug) distilled water while the control group just were given food and water. All groups had blood taking process on the day of 28th. Collected blood samples were used to measure concentration values testosterone, LH, and FSH hormones. Thus, tissue intersect was provided by testis. Tissue differences among experimental and control group were also studied Obtaining results evaluated by one-way ANOVA and- t-test using analysis variance analysis. 

Results: result obtained showed that 75 mm /kg of nettle hydro alcohol extraction, the testosterone level of plasma in comparison with control group in statistical rate p<0.05 decrease significantly. LH and FSH hormone levels between experimental and control group showed insignificant differences. Study of histology intersection showed that sperm rate, spermatogony cell number, initial spermatosit, spermatid, and lidig in experimental group that received maximum extraction had more significant decrease than the rate of control group. Also, weights of body and testis in groups receiving 75 and 50 mg /kg of nettle hydro alcoholic extraction showed significant decrease in experimental group than control group in statistical rate of p<0.05. 

Conclusion :Due to the obtained results and other researches probably nettle extraction might have anti-androgen properties because of containing fitostrol and fitosrogen compounds and also decrease testosterone rate. Histologically, morphological modification in tubuls, inter layers destructive cells, and spermatogenesis epitilium loss were observed.