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Aim and Background: Among more than 23,000 microbial secondary metabolites discovered, 42% of them are separated from actinobacteria. These secondary metabolites have wide range of biological activities such as antibacterial, antifungal, antiparasitic, antiviral, antitumor, immunosuppressive, insecticide, antiinflammatory, antioxidant and other activities. In the past few years, numerous studies have been conducted on these biological activities in the country, but no report has been published about the antioxidant activity of local actinomycetes resources. The purpose of this research is to achieve natural antioxidants with lower physiological hazards associated with local microbial resources.
Materials and Methods: Fifty strains of native actinomycetes preserved at the University of Tehran Microorganism collection were selected randomly and after sporolation and prefermentation and fermentation, bacterial extracts were prepared. At first, antioxidant activity of the extracts was evaluated by DPPH method. These results were evaluated with synthetic antioxidants including ascorbic acid and BHA. Also cytotoxic activity of the extracts was measured on Artemia. Elected strains were recognized with molocular method.
Results: According to the results, 10% of extracts have no antioxidant activity, 20% of the extracts have high antioxidant activity (IC50<200), 32% of extracts with medium antioxidant activity (200 

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Aim and Background: Mentha longifolia with the generic name "Wild Mint, is one of the oldest medicinal plants which have been widely used in Iranian food and medicine. This study was performed to extract the essential oil of Mentha longifolia and analysis of its components and also antioxidant and antibacterial properties of its oil and non-polar compounds, extracted by n-hexan.

Materials and Methods: In this study, the essential oil of M. longifolia was extracted using SDE technique for the first time. The obtained essential oil was analyzed using GC-Mass and its components are identified. Antioxidant activity of the oily compounds was measured via DPPH free radical scavenging activity; while, antibacterial effects were evaluated using disc diffusion method by measuring inhibition zone diameter evaluating n-hexane extract.

Results: The major components of the oil are d-carvone (57.2%) and limonene (15.7%). Some of the essential oil components, identified in this study, are not similar to those mentioned in the previous reports. The results indicate that despite non-polar nature of extract solvent, n-hexane extract has a noticeable inhibitory power on DPPH free radical. Also, it shows very high antimicrobial properties on gram-positive and gram-negative bacteria, which are comparable with standard antibiotics.

Conclusions: This study shows that components extracted by hexane as solvent, despite oily nature of compounds with low polarity, have antioxidant activity and also significant anti-microbial potential which have not been reported for M. longifolia in the literature. 

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Aim and Background:
Anaplastic thyroid cancer, including the most dangerous type of thyroid cancer.and as the most modern cancer treatments are ineffective with side effects, it seems essential to find impressive alternatives treatment. Lavender plant with the scientific name Lavandulla anguostifouliyaof familyLamiaceae, is a Perennial plant that has high nutritional and medicinal value. Therefore, the cytotoxic effect of ethanolic extract of Lavender plant on 8305C cell lines was evaluated.
 
Materials and methods:
In this study, for the first time, the cytotoxic effect of ethanolic extract of Aerial organsLavender plant on 8305c cell lines was evaluated. The Lavender plant in April 2016 of sehezare Tonekabon were collected andstudied; Then the antioxidant activity was evaluated by DPPH⁰ Assay. 8305C cell line was cultured in DMEM with 10% fetal bovine serum. Different concentrations of ethanolic extract of Lavender plant (5, 10, 20, 30, 40 and 50 mg/ml) for 24, 48 and 72 hours were applied on cancer cells 8305C. Then, the viability of cells using MTT assay was considered.
 
Results:
In this study, the free radical scavenging DPPH⁰ equals to 6/27mg/ml was calculated. The results of MTT assay showed that the ethanolic extract of Lavender plant has a cytotoxic effect on the 8305C cell line which is dependent to their doses. Also IC₅₀ of the extract concentration for 8305C cells was obtained to be 5 mg/ml in time 48 hours.
 
Conclusion:
The ethanolic extract of Lavender plant which is dose-dependent could destroy the cancer cells and showed cytotoxic properties. Thus, this plant can be used as a medicinal plant against anaplastic thyroid cancer in wider scope.

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Aim and Background: Plant bioactive substances are a valuable source of various medicines that play an important role in human health. Increasing resistance to different antibiotics has increased the importance of using plant extracts as they have potential sources of antioxidants. Antioxidant compounds of plant origin can protect the body from damage caused by oxidative stress. Recently, the use of natural antioxidants derived from medicinal plants has had medicinal and medical applications. Comparison of the antioxidant activity and total phenolic compounds of Thuja orientalis leaf extracts isolated from the three heights (1, 2, and 3 meters) of Noshahr and Tehran.

Material and Methods: In this experimental study, the leaves of Thuja orientalis were collected in spring from Tehran and Noshahr cities at three heights (1, 2, and 3 meters). Subsequently, the methanolic and aqueous extracts were prepared and their antioxidant activities were evaluated using DPPH and FRAP methods. In addition, the content of the phenolic extract of the extracts was measured by the Folin-Succtile method.
Results: The results of this study showed that both aqueous and the methanolic extracts of T. orientalis exhibited significant total antioxidant activities at a height of 3 meteres. The methanolic extract of T. orientalis collected from Tehran and Noshahr in height of 2 meters showed the howest amounts of antioxidant activity. Moreover, the highest and lowest amounts of total phenolic compounds were belonged to aqueous and the methanolic extracts of T. orientalis collected from Noshahr.  
Conclusion: The results of this study showed that the leaf extract of the C. orientalis can be used as an promising source for the synthesis of antioxidant compounds.