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Aims and Background:Nanotechnology is used to design new formulations of drugs. Also, nanocarriers are utilized for drugs or biologically active substances to improve the therapeutic index. Chemotherapy effectiveness has direct proportion to increase the time of exposing cells near drug. Due to their small size the nanocarriers will then penetrate into the target tissue causing an efficient drug accumulation at the target position.6-gingerol which inhibited efficacy on cancer cell growth in this research preparation as formulation of nanoarchaeosomal PEGylated 6-gingerol and evaluate its impact on cancer cells MCF-7 cell line.
Material and methods:First Halobacterium salinarum lipids were extracted and added 6–gingerol (dissolved in ethanol), Polyethylene glycol (PEG) 2000 and Twee n 80 to it and with the use of Avaporator extract the organic solvent, then were dissolved in buffer phosphate environment and Sonication. Their particle diameter measured with Zeta sizer device and finally evaluated the effect of the formulation cytotoxicity by MTT.
Results:The diameter of the nanoarchaeosomal PEGylated 6-gingerol was equal to 290 nm. The encapsulation efficiency of 6–gingerol in nanoarchaeosomal PEGylated was also equivalent to 96/33 percent, respectively. The Cancer cells against the effect of this formulations showed difference in different doses.
Conclusion:The dimensions of the nanoparticles and the encapsulation efficiency was suitable for targeted drug delivery, and nanoarchaeosoma PEGylated 6–ginger showed cytotoxicity effects on breast cancer cells MCF-7 cell line.

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Aim and Background:
The characteristic of inflammation in the liver is the invasion of inflammatory cells. These cells, with the secretion of inflammatory cytokines such as IL-6 and the alpha-induced tumor necrosis factor, contribute to the disease and damage to the liver. In this study, the anti-inflammatory effect of ginger and lemon juice on an inflammatory factor of IL-6 in liver toxicity induced by thioacetamide in rats was investigated.
Material and methods:
In order to perform the experiment, 55 mouse with an approximately weight of 250-200 grams collected from Isfahan University were used. The samples were randomly divided into 9 treatment groups, one control group and one thioacetamide control group (positive control) (each group with 5 mice). After treatment, each group received different doses of ginger extract and lemon juice, blood samples were taken from the heart under anesthetized conditions and ELISA technique was used to measure the inflammatory factor of IL-6. Finally, the statistical comparison of mean serum IL-6 levels in different groups was performed using SPSS V.20 software and one-way ANOVA test.
Results:
The results showed that consumption of ginger extract and lemon juice significantly decreased serum IL-6 levels. The highest reduction of IL-6 serum levels after thioacetamide treatment was shown in 500 mg/kg ginger and 100% lemon juice combination treatment. This reduction was dose-dependent (P <0.001).
Conclusion:
Thioacetamide causes poisoning and ultimately inflammation of the liver. Extract of ginger and lemon juice in combination with ginger and flavonoids that have anti-inflammatory properties can improve liver parameters in liver inflammation. Ginger extract and sour lemon juice have anti-inflammatory properties and can improve liver parameters in liver inflammation and decrease inflammation by decreasing serum levels of IL-6.

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Aim and Background: Ginger with the scientific name of Zingiber officinale contains the active ingredient Gingerol and many antioxidant and antimicrobial compounds. The aim of this study was to investigate the antimicrobial properties of aqueous and hydro–alcoholic extracts of ginger and to investigate the anti-Alzheimer's effect of its hydro–alcoholic extract by inhibiting the production of amyloid nanofibers.
Materials and Methods: After milling, aqueous and hydro–alcoholic extract of ginger was prepared by soaking method and its antimicrobial effects on Escherichia coli and Staphylococcus aureus were investigated using agar diffusion method and determination of MIC and MBC. Visible spectroscopy was used to determine the inhibitory effect of hydro–alcoholic extract on the production of amyloid filaments.
Results: The results showed that the diameter of the growth inhibition zone due to hydro–alcoholic extract of ginger in the well method was 15 mm for Staphylococcus aureus and 10 mm for Escherichia coli. The MIC and MBC levels for both bacteria were 50 and 100 mg / ml, respectively, and the aqueous extract of ginger had no effect on Escherichia coli. Increasing the concentration of ginger extract in the sample reduced the production of amyloid fibrils, which was associated with decreased absorption and redshift in the visible absorption spectrum of the Congored. The presence of the active ingredient gingerol was confirmed by GC–Mass method up to 34.7%.
Conclusion: Ginger extract with the presence of antimicrobial compounds such as gingerol, with good performance and lower side effects and cost, can be introduced as an effective medicinal plant for reducing the effects of inflammatory and Alzheimer's disease.
 

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Aim and Background:Farnesol and gingerol are two powerful plant active ingredients that have proven anti-cancer and antioxidant effects. In this study, the expression changes of Caspase 8, Matrix metalloproteinases 2, Matrix metalloproteinases 9 and Vascular endothelial growth factor genes were studied in MCF-7 and SKBR3 cancer cell lines treated with niosomes containing farnesol and gingerol.
Material and Methods: MCF-7 and SKBR3 cells were treated with niosome containing farnesol and gingerol, combination of two drugs, single drug niosome formulation and free drug for 48 hours. Gene expression changes were investigated using Real-Time PCR technique and statistical analysis was done at 0.05 level with GraphPad Prism software.
Results: Niosome codelivery containing two drugs (N-Far/Gin) caused a significant increase in the level of caspase 8 gene expression and also a significant decrease in the regulation of the expression of Matrix metalloproteinases 2, Matrix metalloproteinases 9, and Vascular endothelial growth factor genes (P<0/001). It had a higher significance level than the treatment with other formulations.
Conclusion: It seems that farnesol and gingerol-loaded niosomes have great anti-apoptotic, anti-metastatic, and anti-angiogenic potential in the prevention of breast cancer. Further in vivo experiments and clinical studies can elucidate the potential of N-Far/Gin to be applied as a medicinal agent in breast cancer treatment.