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Showing 3 results for Nanoliposome

Neda Dadgar, Seyed Ebrahim Alavi, Maedeh Koohi Moftakhari Esfahani, Mohsen Chiani, Sepideh Torabi, Azim Akbarzadeh,
Volume 4, Issue 13 (3-2014)
Abstract

Aim and Background: Nano carriers, amongst which liposomes have remarkable significance, have recently revolutionized the treatment of a large number of diseases one of which is known to be cancer. Artemisinin is one of the drugs which are used in cancer treatment, however, despite its effectiveness it has some side effects which can be reduced by using liposomes. 
Materials and Methods: In order to produce nanoliposomal artemisinin, particular proportions of phosphatidylcholine, cholesterol and artemisinin were mixed together. Afterward, the diameters of liposomes we determined by means of Zeta sizer system. The encapsulation efficiency was estimated through spectrophotometery method. The amount of released artemisinin from the formulation was measured by dialysis for 24 hours. Cytotoxicity amount of pegylated nanoliposomal artemisinin was measured by means of MTT assay. 
Results: The mean diameter of nanoliposomes was 455 nm. The encapsulation efficiency and the amount of released drug from artemisinin formulation and pegylated nanoliposomal formulation respectively were 5/3±62/91 and 17/5. The results show that the ratio of the IC50 of the prepared formulation to standard drug is a smaller amount. 
Conclusions: This study explains that the ratio of Cytotoxicity amount of this drug has been decreased compared to the standard drug, which can be achieved by nanoliposome preparation and pegylation of artemisinin.

Mohammadali Ghanbari, Ebrahimi Shaham Abadi, Zahra Saffari, Azim Akbarzadeh Khiyavi,
Volume 6, Issue 21 (1-2016)
Abstract

Aim and Background: Hepatocellular carcinoma (HCC) -an aggressive malignancy with high rate of mortality- is the third cause of cancer related death, worldwide. Cisplatin is a chemotherapy drug used for treatment of HCC. However, serious side effects of drug limit the therapeutic administer dose.  Nanotechnology based devices such as liposome nanoparticles are capable to overcome these drawbacks and simultaneously improve the efficacy of drugs.

Materials and Methods: Cisplatin encapsulated liposomal nanoparticles were successfully constructed using lecithin, Cholesterol, PEG3350and CisPlatin. After characterization in vitro efficacy of nanodrug was evaluated with IC50 Pharm Microsoft.

Results: The size and zeta potential of nanoparticles were determined to be 470 nm and -20 mV.

The cytotoxicity of drug loaded nanoparticles was increased by 33% compared to the free drug on the Hepatocellular carcinoma cell line HepG2 using MTT assay.

Conclusion: The results of study suggested evaluating the efficacy of nanodrug on the animal model of HCC and also the cytotoxicity of pegilated nanoliposome drug is more than the free drug.


Masoomeh Shirzad, Saeed Jamehbozorgi, Hamid Reza Aghabozorg , Azim Akbarzadeh,
Volume 7, Issue 25 (1-2017)
Abstract

Aim & Background: Drug delivery, and using of nanocarriers like pegylated nanoliposomal cisplatin are known as one of the effective method for cancer treatment. In this study, various nanoparticle formulations of cisplatin were prepared and efficacy of the prepared formulations were evaluated in vitro environment. Materials and Method: Reverse phase evaporation technique was used to obtain the pegylated nanoliposomal cisplatin. Cytotoxicity of pegylated nanoliposomal cisplatin were determined in A2780CP ovarian cancer cell lines by using MTT assay. Loading percentage of cisplatin was obtained by inductively coupled plasma spectroscopy. Results: The mean size, and zeta potential of nanodrug formulations were obtained 100 ± 2.2 nm, and -18.1 ±1.5 mV , respectively. Cytotoxicity of free drug and nanodrug (IC50 values) were estimated 76.6 ± 3.1 µg/mL , and 46.6 ± 2.3 µg/mL in A2780CP ovarian cancer cell lines, respectively. Conclusion: Results of this study showed that liposomal nanoparticles could be considered as a suitable nanocarrier for cisplatin. It showed that cytotoxicity of nanodrug was increased significantly in comparison to free drug.

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