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Aim and Background: Ascorbic acid (vitamin C) is a white powder and non-toxic. VC is the most important antioxidant. This vitamin is not stable enough in aqueous solution. The aim of this work is to encapsulate ascorbic acid within nanomicelle in order to increase the stability of vitamin, fat-soluble and higher concentrations drug delivery.
Materials and Methods: Using surfactant Tween 80 and α-tocopherol in stable temperature conditions, nanomicelle was developed. Encapsulation efficiency was calculated by spectrophotometric method. The morphology of nanomicelle was examined with electron microscope TEM operating and Size measurements of the samples were obtained by Dynamic Light Scattering Instrument (Nano-ZS Malvern, UK).
Results: The mean diameter and encapsulation efficiency of nanomicelle ascorbic acid is, respectively, 100 nm and 70%.
Conclusion: This study showed that ascorbic acid can be encapsulated into nanomicelle and protected against environmental factors such as temperature, humidity, pH and light also with this method the fat-solubility of vitamin can be achieved.