Volume 10, Issue 37 (12-2019)
NCMBJ 2019, 10(37): 9-20 |
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Heidari H, Mohamadynejad P. The association of rs10573247 polymorphism in 3ˈ-UTR of HMGA2 gene with risk of gastric cancer. NCMBJ 2019; 10 (37) :9-20
URL: http://ncmbjpiau.ir/article-1-1250-en.html
URL: http://ncmbjpiau.ir/article-1-1250-en.html
Department of biology, Faculty of Science, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
Abstract: (3422 Views)
Aim and Background: The HMGA2 protein is one of the transcription factors that regulates the evolution and differentiation of the cells. Studies have shown that changes in the expression of the HMGA2 gene can play an important role in preventing tumor progression and its metastasis. In this study, we investigated the association between rs10573247 polymorphism in the 3-UTR region of HMGA2 gene and the risk of gastric cancer.
Material and Methods: Genomic DNA from blood sample of 100 patients with gastric cancer and 100 healthy individuals were extracted A part of the HMGA2 gene, including rs10573247 polymorphism, was amplified by PCR technique. After, the PCR product was treated with EaR1 enzyme and the genotype of each individual was determined. Finally, the risk of gastric cancer was assessed with the statistical tests of χ2 and logistic regression.
Results: The statistical analysis of allelic and genotypic association of rs10573247 polymorphism with the risk of gastric cancer showed that there was not significant relationship between different alleles of rs10573247 polymorphism (P = 0.127) and none of its genotypes with gastric cancer risk.
Conclusion: It seems none of the rs10573247 polymorphism genotypes in the HMGA2 gene were associated with the risk of gastric cancer.
Material and Methods: Genomic DNA from blood sample of 100 patients with gastric cancer and 100 healthy individuals were extracted A part of the HMGA2 gene, including rs10573247 polymorphism, was amplified by PCR technique. After, the PCR product was treated with EaR1 enzyme and the genotype of each individual was determined. Finally, the risk of gastric cancer was assessed with the statistical tests of χ2 and logistic regression.
Results: The statistical analysis of allelic and genotypic association of rs10573247 polymorphism with the risk of gastric cancer showed that there was not significant relationship between different alleles of rs10573247 polymorphism (P = 0.127) and none of its genotypes with gastric cancer risk.
Conclusion: It seems none of the rs10573247 polymorphism genotypes in the HMGA2 gene were associated with the risk of gastric cancer.
Type of Study: Research Article |
Subject:
Cellular and molecular
Received: 2019/12/5 | Accepted: 2019/12/5 | Published: 2019/12/5
Received: 2019/12/5 | Accepted: 2019/12/5 | Published: 2019/12/5
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