Volume 10, Issue 40 (8-2020)                   NCMBJ 2020, 10(40): 103-113 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Siasi E, Aleyasin A. Association of rs737008 in PRM1 and rs4780356 in PRM2 Polymorphisms with Idiopathic Infertility in Iranian men. NCMBJ 2020; 10 (40) :103-113
URL: http://ncmbjpiau.ir/article-1-1318-en.html
Medical genetic department, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran.
Abstract:   (2492 Views)
Aim and Background: Histones are replaced by protamines to package sperm head DNA during mammalian spermatogenesis. Protamine genes variation cause sperm DNA damage and is affect infertility in men. Therefore this study aim was investigation on association of two rs737008 in PRM1 gene and rs4780356 in PRM2 gene polymorphisms with azoospermia and oligospermia in Iranian idiopathic infertile men.
 
 
Materials and Methods: DNA extraction from blood samples of 96 idiopathic infertile men with azoospermia and oligospermia and 100 normal control men. Prevalance of two studied polymorphisms was identified by restriction fragment length polymorphism (PCR-RFLP). Then results were confirmed with sequencing.
 
 
Results: A mutant allele frequency of rs737008 in PRM1 gene polymorphism was difference in patient and control groups but statistical analysis showed no significant association between this polymorphism prevalance among case and control groups (P>0.05). By genotyping shown no existent rs4780356 in PRM2 gene polymorphism in anyone of case and control groups.
 
 
Conclusion: This study finding indicated there was not association with prevalence of two rs737008 in PRM1 gene and rs4780356 in PRM2 gene polymorphisms with oligospermia and azospermia and idiopatic male infertility in Iranian population. More studies need to demonstrate the role of these two polymorphisms with idiopathic infertility in Iranian men.
 
Full-Text [PDF 4511 kb]   (978 Downloads) |   |   Full-Text (HTML)  (1258 Views)  
Type of Study: Research Article | Subject: Cellular and molecular
Received: 2020/10/18 | Accepted: 2020/08/31 | Published: 2020/08/31

References
1. Azizi F, Omrani M.D, Sadighi Gilani M.A, Hosseini J. The Genetic Causes of Male Infertility in Iranian Population; A systematic Review. Men’s Health Journal, 2018; 2 (1); e1.
2. Venkatesh S, Kumar R, Deka D, Deecaraman M, Dada R. Analysis of sperm nuclear protein gene polymorphisms and DNA integrityin infertile men. Systems Biology in Reproductive Medicine, 2011; 57: 124–132.
3. Wang T, Gao H, Li W, Liu C. Essential Role of Histone Replacement and Modifications in Male Fertility. Frontiers in Genetics, 2019; 10(962): 1-15.
4. Park Sh. Genetic Factors and Environmental Factors Affecting Male Infertility. International Research Journal of Advanced Engineering and Science, 2016; 1(3): 115-118.
5. Dehghanpour F, Farzaneh Fesahat F, Miresmaeili S.M, Zare Mehrjardi E, Honarju A, Talebi A.L. Analysis of PRM1 and PRM2 Polymorphisms in Iranian Infertile Men with Idiopathic Teratozoospermia. International Journal of Fertility and Sterility, 2019; 13(1): 77-82.
6. Raheem A.A, Ralph D. Male infertility: causes and investigations. Trends in urology and mens health, 2011; 2(5): 8-11.
7. Bisht S, Mathur P, Dada R. Protamines and their role in pathogenesis of male infertility. Transl Cancer Res, 2016; 5(3):324-326.
8. Tavalaee M, Ghorbani R, Nasr-Esfahani MH. The Role of Sperm Protamine in Pathogenesis of Male Infertility. Journal of Fasa University of Medical Sciences, 2019; 9 (2): 1357-1367.
9. He Q, Deng L, Deng S, Jin T. Association of protamine1 gene c.-190C>A polymorphism with male infertility risk: a meta-analysis. Int J Clin Exp Med, 2019; 12(4):3047-3055.
10. Nabi1 A, Khalili M.A, Moshrefi M, Sheikhha M.H, Zare Mehrjardi E, Ashrafzadeh H.R. Polymorphisms in protamine 1 and 2 genes in asthenozoospermic men: A case-control study. Int J Reprod BioMed, 2018; 16(6): 379-386.
11. Tanaka H, Miyagawa Y, Tsujimura A, Matsumiya K, Okuyama A.Y.N. Single-nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations. Molecular Human Reproduction, 2003; 9: 69-73.
12. Gazouez C, Oriola J, De Mateo S, Vidal-Taboada J.M, Ballesca J.I. A comman protamine 1 promoter polymorphism (C190A) correlates with abnormal sperm morphology and increased protamine P1/P2 ratio in infertile patients. Journal of Andrology, 2008; 29: 540-548.
13. Iguchi N, Yang S, Lamb D.J. An SNP in protamine 1: a possible genetic cause of male infertility? J Med Genet, 2006; 43: 382-384.
14. Imken L, Rouba H, EI Houate B, Louanjli N, Barakat A, Chafik A. Mutations in the protamine locus: association with spermatogenic failure? Molecular Human Reproduction, 2009; 7: 1-22.
15. Jiang W, Shi L, Liu H, Cao J, Zhu P, Yu M, Guo Y, Cui Y, Xia X. Systematic review and meta‐analysis of the genetic association between protamine polymorphism and male infertility. Andrologia, 2018; 50(5): e12990.
16. Jiang W, Sun H, Zhang J, Zhou Q, Wu Q, Li T, i Zhang C, Li W, Zhang M, Xia X. Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis. Scientific Reports, 2015; 5(15300): 1-11.
17. Jiang W, Zhu P, Zhang J, Wu Q, Li W, Liu S, Ni M, Yu M, Cao J, Li Y, Cui Y, Xia X. Polymorphisms of protamine genes contribute to male infertility susceptibility in the Chinese Han population. Oncotarget, 2017; 8(37): 61637-61645.
18. Jodar M, Oriola J, Mestre G, Castillo J, Giwercman A, Vidal‐Taboada J. Polymorphisms, haplotypes and mutations in the protamine 1 and 2 genes. Int J Androl, 2011; 34: 470-485.
19. Aydos O.S.E, Hekmatshoar Y, Altınok B, Özkan T, Şakirağaoğlu O, Karadağ A, Kaplan F, Ilgaz S, Taşpınar M, Yükselen I, Sunguroğlu A, Aydos K. Genetic Polymorphisms in PRM1, PRM2, and YBX2 Genes are Associated with Male Factor Infertility. Genet Test Mol Biomarkers, 2018; 22(1):55-61.
20. Tüttelmann F, Křenková P, Römer S, Nestorovic A.R, Ljujic M, Štambergová A. A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts. Int J Androl, 2010; 33: e240-e280.
21. Al Zeyadi M, AL-Salimi A.S.M, Albaldawy M.T. Single Nucleotide Polymorphism in Protamine 1 and Protamine 2 genes in fertile and infertile for men of Al-Najaf City. J. Phys.: Conf. Ser, 2019; 1234 (012081): 1-10.
22. Salamian A, Ghaedi K, Razavi S, Tavalaee M, Tanhael S, Tavalaee M, Salahshouri I, Gourabi H.M.H. Single nucleotide polymorphism analysis of protamine genes in infertile men. Royan Institute International Journal of Fertility and Sterility, 2008; 2(1): 13-18.
23. Aston K.I, Krausz C, Laface I, Ruiz-Castane E, Carrell D.T. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. Hum Reprod, 2010; 25: 1383-1397.

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | New Cellular and Molecular Biotechnology Journal

Designed & Developed by : Yektaweb