Volume 10, Issue 40 (8-2020)                   NCMBJ 2020, 10(40): 91-102 | Back to browse issues page

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jafari hafshejani R, gheibi hajivar F, nikkhah S. Effect of Silymarin on Blood Glucose and Hnf1a Gene Expression in Streptozotocin-Induced Diabetic Male Wistar Rats. NCMBJ. 2020; 10 (40) :91-102
URL: http://ncmbjpiau.ir/article-1-1320-en.html
Department of Biology, Science Faculty, Islamic Azad University, Shahrekord Branch, Shahrekord, Iran
Abstract:   (1073 Views)
Aim and Background: Today, research has shown that medicinal plants have fewer side effects than industrial and chemical judges. On the other hand, studies indicate the important role of Hnf1a gene in diabetes, so the aim of this study was to investigate the effect of silymarin on blood sugar and expression of Hnf1a gene in male Wistar rats diabetic with streptozoto.
 
Material and methods:  42 male rats were randomly selected and divided into seven groups. Sixty diabetic rats with diabetic streptozotocin have been measured and their fasting blood glucose was measured. After the end of the period, the rats were anesthetized with the drug. A portion of the pancreatic tissue was isolated and used to evaluate the expression of Hnf1a gene using Real Time RT PCR..
 
Results: Evaluation of Hnf1alpha at a dose of 150 mg / kg in silymarin-receiving rats showed a significant decrease in Hnf1alpha gene expression and was introduced as an effective dose (P-Value <0.05) due to the use of silymarin in the country. It is not common, in future research, more importance can be given to the effects of silymarin and it can be considered as an effective drug.
 
Conclusion: Based on the results of this study, it can be concluded that silymarin reduces blood sugar in diabetes and, if confirmed in extensive studies, can be considered as a therapeutic target in diabetes.
 
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Type of Study: Research Article | Subject: Cellular and molecular
Received: 2020/10/21 | Accepted: 2020/08/31 | Published: 2020/08/31

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