Volume 13, Issue 50 (3-2023)
NCMBJ 2023, 13(50): 67-76 |
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Asadi A, Emadi A, Asadi N. Study of immune responses of enterotoxemia vaccine in Kermani sheep and goats. NCMBJ 2023; 13 (50) :67-76
URL: http://ncmbjpiau.ir/article-1-1535-en.html
URL: http://ncmbjpiau.ir/article-1-1535-en.html
Department of Microbiology, Razi Vaccine and Serum Research Institute karaj , Iran
Abstract: (1066 Views)
Aim and Background: Enterotoxemia occurs following absorption of large amounts of toxin through the intestinal wall. The causing agent of this disease is clostridium perfringens. The present study Comparison of Immune Responses Following the Administration of Enterotoxaemia Vaccine in kermani Sheep and Goats.
Material and methods: Two groups consisting 30 sheep and 30 healthy goats of the same breedselected. Each of these groups was then divided into three sub groups of ten. One sub group of ten sheep and goats formed the control group, which received no vaccination in the course of the study. The second sub group received vaccination only once, and the last sub group was vaccinated twice. Blood samples were taken from these 60 animals on day 1, 15, 30, 45, 60 and 75 after vaccination, and antibody titer and duration of immunity were determined by ELISA test.
Results: The antibody titer during the study in the control sub group was zero. In sub group 2 sheep that received only one dose of vaccine had a mean antibody titer of 0. 428 and in goats 0. 097. In sub group 3 sheep that received two vaccinations, the mean antibody titer was 0.772 and in goats it 0. 408 was. Immunity durabity longer in sheep than in goats.
Conclusion: The results showed significant differences in antibody titer and duration of immunity between animals that received booster doses compared to those that were vaccinated only once. Moreover, antibody titer approached zero much earlier in goat than that in sheeps.
Material and methods: Two groups consisting 30 sheep and 30 healthy goats of the same breedselected. Each of these groups was then divided into three sub groups of ten. One sub group of ten sheep and goats formed the control group, which received no vaccination in the course of the study. The second sub group received vaccination only once, and the last sub group was vaccinated twice. Blood samples were taken from these 60 animals on day 1, 15, 30, 45, 60 and 75 after vaccination, and antibody titer and duration of immunity were determined by ELISA test.
Results: The antibody titer during the study in the control sub group was zero. In sub group 2 sheep that received only one dose of vaccine had a mean antibody titer of 0. 428 and in goats 0. 097. In sub group 3 sheep that received two vaccinations, the mean antibody titer was 0.772 and in goats it 0. 408 was. Immunity durabity longer in sheep than in goats.
Conclusion: The results showed significant differences in antibody titer and duration of immunity between animals that received booster doses compared to those that were vaccinated only once. Moreover, antibody titer approached zero much earlier in goat than that in sheeps.
Type of Study: Research Article |
Subject:
Physiology
Received: 2021/06/13 | Accepted: 2022/06/22 | Published: 2023/03/21
Received: 2021/06/13 | Accepted: 2022/06/22 | Published: 2023/03/21
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