Volume 14, Issue 53 (12-2023)
NCMBJ 2023, 14(53): 115-125 |
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Allaedini Taleghani R, Sabokbar A, Momeni Z. A comparative survey in vitro effect of aqueous and alcoholic extracts of Sumac fruit on Trichomonas vaginalis and Candida albicans. NCMBJ 2023; 14 (53) :115-125
URL: http://ncmbjpiau.ir/article-1-1638-en.html
URL: http://ncmbjpiau.ir/article-1-1638-en.html
Department of Microbiology, karaj Branch, Islamic Azad University, Karaj, Iran Sabokbar , sabokbar@kiau.ac.ir
Abstract: (515 Views)
Aim and Background: Plants are a rich source of bioactive chemical compounds that play an important role in the prevention and treatment of infectious diseases. In this study, the ability of aqueous and ethanolic extracts of sumac (Rhus coriaria) fruit to inhibit the growth of Trichomonas vaginalis and Candida albicans were investigated in vitro.
Material and methods: Extraction of sumac fruit was done by soaking and stirring with water and ethanol and its antimicrobial effects were evaluated by Broth microdilution method by determining the minimum inhibitory concentration (MIC).
Results: The 50% inhibitory concentration (IC50) of ethanolic extract against Trichomonas vaginalis was 1.8 mg/ml and for aqueous extract was 3.55 mg/ml in 24 hours. No concentration of the aqueous extract of Sumac fruit was able to inhibit the growth of Candida albicans, while the ethanolic extract at 60 mg/ml inhibited the growth of Candida albicans after 24 hours.
Conclusion: Sumac fruit extracts can be considered as a potential alternative to chemical drugs in the treatment of Trichomonas vaginalis infections, but these compounds have not shown favorable antifungal results against Candida albicans.
Material and methods: Extraction of sumac fruit was done by soaking and stirring with water and ethanol and its antimicrobial effects were evaluated by Broth microdilution method by determining the minimum inhibitory concentration (MIC).
Results: The 50% inhibitory concentration (IC50) of ethanolic extract against Trichomonas vaginalis was 1.8 mg/ml and for aqueous extract was 3.55 mg/ml in 24 hours. No concentration of the aqueous extract of Sumac fruit was able to inhibit the growth of Candida albicans, while the ethanolic extract at 60 mg/ml inhibited the growth of Candida albicans after 24 hours.
Conclusion: Sumac fruit extracts can be considered as a potential alternative to chemical drugs in the treatment of Trichomonas vaginalis infections, but these compounds have not shown favorable antifungal results against Candida albicans.
Type of Study: Research Article |
Subject:
Physiology
Received: 2024/02/3 | Accepted: 2023/12/22 | Published: 2023/12/22
Received: 2024/02/3 | Accepted: 2023/12/22 | Published: 2023/12/22
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