Volume 14, Issue 54 (5-2024)
NCMBJ 2024, 14(54): 35-41 |
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zekri A, Modarressi M H, Sotoodenejadnematalahi F. Investigation of Aurora Kinase-B gene expression in breast cancer patients. NCMBJ 2024; 14 (54) :35-41
URL: http://ncmbjpiau.ir/article-1-1656-en.html
URL: http://ncmbjpiau.ir/article-1-1656-en.html
Department of Medical Genetics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran , azekri87@gmail.com
Abstract: (569 Views)
Aim and Background: Breast cancer remained the leading cause of cancer-related death among women worldwide. Despite considerable advances in early detection and effective therapy, developing chemoresistance and metastatic spread to distant organs is still a pressing clinical challenge. The present study aims to investigate the role of Aurora-B as a potential oncogene in the progression of breast cancer.
Material and Methods: Forty breast tumor samples and paired adjacent non-tumor tissues were collected. RNA was extracted and converted to cDNA according to manufacture protocols. The expression of Aurora-B was assessed using quantitative real-time PCR. The relationship between gene expression and the pathological features of the tumors, and the hormone receptors status of the patient’s tumors were also analyzed.
Results: We found a significant overexpression of the Aurora-B gene in tumor samples compared to adjacent normal tissue (p value < 0.05). Moreover, the overexpression of Aurora-B was more increased in IDC tumors in compare to ILC breast tumors. There was not significant change between pre- and post-menopause periods.
Conclusion: Overexpression of oncogenic Aurora-B is associated with the progression of breast cancer. Aurora-B may represent an emerging therapeutic target in breast cancer treatment.
Material and Methods: Forty breast tumor samples and paired adjacent non-tumor tissues were collected. RNA was extracted and converted to cDNA according to manufacture protocols. The expression of Aurora-B was assessed using quantitative real-time PCR. The relationship between gene expression and the pathological features of the tumors, and the hormone receptors status of the patient’s tumors were also analyzed.
Results: We found a significant overexpression of the Aurora-B gene in tumor samples compared to adjacent normal tissue (p value < 0.05). Moreover, the overexpression of Aurora-B was more increased in IDC tumors in compare to ILC breast tumors. There was not significant change between pre- and post-menopause periods.
Conclusion: Overexpression of oncogenic Aurora-B is associated with the progression of breast cancer. Aurora-B may represent an emerging therapeutic target in breast cancer treatment.
Type of Study: Research Article |
Subject:
Physiology
Received: 2024/05/12 | Accepted: 2024/05/12 | Published: 2024/05/12
Received: 2024/05/12 | Accepted: 2024/05/12 | Published: 2024/05/12
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