Volume 14, Issue 55 (6-2024)
NCMBJ 2024, 14(55): 31-40 |
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Yazdandoust S, Parizadeh S M R, Ghayour-Mobarhan M, Yaghmaei P, Sahebkar A H. Comparison of high-density lipoprotein (HDL) level and function for the diagnosis of coronary artery disease. NCMBJ 2024; 14 (55) :31-40
URL: http://ncmbjpiau.ir/article-1-1677-en.html
URL: http://ncmbjpiau.ir/article-1-1677-en.html
Shima Yazdandoust 
, Seyyed Mohammad Reza Parizadeh , Majid Ghayour-Mobarhan , Parichehreh Yaghmaei , Amir Hossein Sahebkar
, Seyyed Mohammad Reza Parizadeh , Majid Ghayour-Mobarhan , Parichehreh Yaghmaei , Amir Hossein Sahebkar
NESCO International Center for Basic Medical Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran , ghayourm@mums.ac.ir
Abstract: (251 Views)
Aim and Background: High-density lipoprotein (HDL) is known to be a protective factor against coronary artery disease (CAD). In recent studies, investigating the function of HDL more than measuring its level has attracted the attention of researchers. Therefore, the aim of present study was to compare the level and function of HDL for the diagnosis of CAD.
Materials and Methods: This study (case-control) was conducted on 853 people, including 572 patients with CAD and 281 healthy subjects. Lipid profile and hs-CRP were measured by enzymatic and immunoturbidometric methods, respectively. HDL function was evaluated by measuring the activity of the paraoxonase 1 (PON1) enzyme and its effect on paraoxon substrate using the spectrophotometric method. ROC curve analysis was used to compare the detection power of the studied factors. Multivariate logistic regression analysis was used to identify risk factors that have an independent relationship with CAD.
Results: A significant decrease in the level and function of HDL was observed in patients with CAD than in healthy individuals (p<0.001). Based on ROC curve analysis, the area under the curve (AUC) for PON1 enzyme activity was higher than HDL-C. The results of multivariable logistic regression analysis showed that diabetes, hypertension, smoking, hs-CRP, and PON1 enzyme activity are independent risk factors for CAD.
Conclusion: Evaluation of HDL function is a more appropriate criterion for diagnosing CAD than measuring its level. PON1 enzyme activity is suggested as a diagnostic biomarker for CAD.
Materials and Methods: This study (case-control) was conducted on 853 people, including 572 patients with CAD and 281 healthy subjects. Lipid profile and hs-CRP were measured by enzymatic and immunoturbidometric methods, respectively. HDL function was evaluated by measuring the activity of the paraoxonase 1 (PON1) enzyme and its effect on paraoxon substrate using the spectrophotometric method. ROC curve analysis was used to compare the detection power of the studied factors. Multivariate logistic regression analysis was used to identify risk factors that have an independent relationship with CAD.
Results: A significant decrease in the level and function of HDL was observed in patients with CAD than in healthy individuals (p<0.001). Based on ROC curve analysis, the area under the curve (AUC) for PON1 enzyme activity was higher than HDL-C. The results of multivariable logistic regression analysis showed that diabetes, hypertension, smoking, hs-CRP, and PON1 enzyme activity are independent risk factors for CAD.
Conclusion: Evaluation of HDL function is a more appropriate criterion for diagnosing CAD than measuring its level. PON1 enzyme activity is suggested as a diagnostic biomarker for CAD.
Type of Study: Research Article |
Subject:
Physiology
Received: 2024/08/10 | Accepted: 2024/06/30 | Published: 2024/06/30
Received: 2024/08/10 | Accepted: 2024/06/30 | Published: 2024/06/30
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