Volume 14, Issue 56 (9-2024)
NCMBJ 2024, 14(56): 1-14 |
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Mozaffari Z. Investigating the effect of nanoparticles on activated intracellular pathways in male and female reproductive organs Running title: Investigating the effect of nanoparticles. NCMBJ 2024; 14 (56) :1-14
URL: http://ncmbjpiau.ir/article-1-1698-en.html
URL: http://ncmbjpiau.ir/article-1-1698-en.html
Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran , Mozaffari_Ziba882@yahoo.com
Abstract: (203 Views)
Aim and Background: Due to an increasing use of nanoparticles in various industrial sectors such as cosmetics, food additives, and medicine (as pharmaceutical carriers) over the last decades, the exposure of humans to these nanoparticles has increased.
Material and Methods: This study has undertaken a systematic review of the literature on the subject in the ten-year period from 2012 to 2023. The research databases Pubmed, Google Scholar, Nature, Science Direct, and Elsevier have been used to collate the relevant literature.
Results: In this review study, the reproductive toxicity of nanoparticles has been investigated by reviewing the articles. Previous studies have indicated the toxic effects of nanoparticles on various systems, especially the reproductive system. In other words, nanoparticles can pass through barriers such as the blood-testicular barrier and reach reproductive systems, and accumulate in them.
Conclusion: Accumulation of nanoparticles in reproductive organs with induction of reactive oxygen species is associated with the degradation of sertoli cells, leydig cells and germ cells, follicles and ovarian granulosa, which damage organs such as testes, ovaries, and uterus and ultimately lead to genital tract dysfunction. The present study examines the reproductive toxicity of a number of nanoparticles on the reproductive organs.
Material and Methods: This study has undertaken a systematic review of the literature on the subject in the ten-year period from 2012 to 2023. The research databases Pubmed, Google Scholar, Nature, Science Direct, and Elsevier have been used to collate the relevant literature.
Results: In this review study, the reproductive toxicity of nanoparticles has been investigated by reviewing the articles. Previous studies have indicated the toxic effects of nanoparticles on various systems, especially the reproductive system. In other words, nanoparticles can pass through barriers such as the blood-testicular barrier and reach reproductive systems, and accumulate in them.
Conclusion: Accumulation of nanoparticles in reproductive organs with induction of reactive oxygen species is associated with the degradation of sertoli cells, leydig cells and germ cells, follicles and ovarian granulosa, which damage organs such as testes, ovaries, and uterus and ultimately lead to genital tract dysfunction. The present study examines the reproductive toxicity of a number of nanoparticles on the reproductive organs.
Keywords: Nanoparticles, Reproductive toxicity, Reactive oxygen species, male and female reproductive organs.
Type of Study: Review Article |
Subject:
Cellular and molecular
Received: 2024/11/24 | Accepted: 2024/09/22 | Published: 2024/09/22
Received: 2024/11/24 | Accepted: 2024/09/22 | Published: 2024/09/22
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