Phage display technology and development of its application in the preparation of antivenoms and other biological products

Yekani, Reza; Samianifard , Maedeh; Nazari ,  Ali

Volume 16, Issue 61 (3-2026) NCMBJ 2026, 16(61): 1-20 | Back to browse issues page

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Yekani R, Samianifard M, Nazari A. Phage display technology and development of its application in the preparation of antivenoms and other biological products. NCMBJ 2026; 16 (61) :1-20
URL: http://ncmbjpiau.ir/article-1-1795-en.html

Phage display technology and development of its application in the preparation of antivenoms and other biological products

Reza Yekani

, Maedeh Samianifard

, Ali Nazari ^*

- purification Laboratory, Research and Development Management, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, Iran.

Abstract: (75 Views)

Phage display technology is an advanced method in biotechnology that enables the identification and selection of target molecules through the display of peptides or proteins on the surface of bacteriophages. This technology plays a pivotal role in various biological fields, including protein engineering, drug discovery, diagnostic tool development, and the design of advanced therapies. One of its significant applications is in the production of effective antitoxins, offering an efficient alternative to traditional methods by identifying and neutralizing antibodies against toxins. Additionally, in cancer research, phage display has opened new avenues for the development of targeted and personalized therapies by identifying specific ligands and antibodies. This technology has made remarkable contributions to improving antibody-based therapies, targeted drug delivery systems, and precise disease diagnosis, enabling reduced side effects and enhanced efficiency. Other achievements include aiding in the identification of protein epitopes, the development of recombinant vaccines, and the screening of biological molecules. Comprehensive studies reveal that phage display, as a powerful tool, has significantly advanced biological and medical sciences. Its integration with technologies like artificial intelligence holds the potential for even greater breakthroughs. Given the versatility and efficiency of this method, phage display is expected to be increasingly utilized in emerging fields such as the treatment of chronic and infectious diseases, driving transformative progress in biological and medical research

Keywords: Phage Display, Protein Engineering, Drug Discovery, Targeted Therapies, Neutralizing Antibodies, Disease Diagnosis, Recombinant Vaccines.

Full-Text [PDF 2323 kb] (55 Downloads)

Type of Study: Review Article | Subject: Biochemistry
Received: 2026/03/3 | Accepted: 2026/03/1 | Published: 2026/03/1