Aim and Background:Nowadays, applying nanocarriers has increased dramatically in drug delivery systems. Niosome is one of the nanocarriers with non-ionic surfactant which increases the stability of drug in the body. Since using cisplatin in treatment of cancer has some side effects, cisplatin was nanoniosomed.

Material and methods:To prepare niosome, span 60 and cholesterol were used. Mean diameter of particles was determined by Zeta sizer. Encapsulation efficiency and drug release were measured by spectrophotometry method. Cytotoxicity effect of the formulation on C6 cell line was studied by MTT assay.

Results:Mean diameter of particles was verified in scale of nano. Encapsulation efficiency and released in 48 hours were be 43.6% and 97%, respectively. The cytotoxicity effect of nanoniosomal cisplatin was 38.6 µg/ml.

Conclusion:The present study showed that to reduce side effects of cisplatin and increase its toxicity, nanoniosomal formulation can be used.