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Aim and Background: Considering the widespread application of silver nanoparticles in daily life, the side effects to humans, it is growing increasingly. But the effects of silver nanoparticle on the stage of embryonic development are not fully understood. This study investigates the potential teratogenic effects of silver nanoparticles on the developmental stages of fetal rats. Materials and Methods: silver nanoparticle concentrations of 0, 125, 750 and 1500 mg / kg / day orally (gavage) administrated from days sixth to nineteenth pregnancy. The embryos harvested via cesarean on day nineteenth gestation. Weight and CR (Crown-Rump) embryos separately were measured. The CR measured by Image j software. The length of the tail, the limbs, fingers and toes, edema, eyes and nose during all the embryos were examined Results: According to data obtained, we could not find any significant different in the length of the tail, the limbs, fingers, edema, eyes and nose between the experiments and control groups. The weight and CR of experiments embryos were increased in compare with control groups and shows significant different except that the mean the 125 mg / kg / day grout that did not show significant different. Conclusion: Based on these results, we can conclude that silver nanoparticles can effect on embryo development stages. These changing are dose dependent and can increase the weight and CR of rat embryo at 19th day gestation.

Keywords: silver nanoparticles, CR, fetal development, morphology, erotogenic

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