Volume 14, Issue 56 (9-2024)
NCMBJ 2024, 14(56): 15-41 |
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Azimzadeh S, Salimian J, Ahmadigorgani A. Modeling the transcriptome pattern of airway epithelial cells effective in the progression of chronic obstructive pulmonary disease. NCMBJ 2024; 14 (56) :15-41
URL: http://ncmbjpiau.ir/article-1-1699-en.html
URL: http://ncmbjpiau.ir/article-1-1699-en.html
Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran & Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran , azimzadeh.jam.sadegh@gmail.com
Abstract: (414 Views)
Aim and Background: Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disease that has a significant impact on community health. Airway epithelial cells play a crucial role in maintaining airway health as a defensive barrier against external threats. In this study, using transcriptome data modeling, genes associated with COPD have been identified in airway epithelial cells. The main objective of this study was to identify functional modules related to COPD in these cells.
Material and methods: The role of airway epithelial cells in COPD was investigated in this study using transcriptome data modeling. Transcriptome samples from non-smoker groups and patients at different stages of the disease were analyzed, and functional modules were identified using gene co-expression network analysis and gene regulatory network plotting methods.
Results: The genes PLAG1, CYP4Z1, ME1, MUCL1, and TLR5 have the highest betweenness centrality scores and the genes CYP4Z1, PLAG1, SLITRK6, GLI3, and CABYR have the highest degrees in the resulting functional cluster.
Conclusion: A better understanding of the biological mechanisms and contributing factors in COPD may help to develop to new approaches for diagnosis, prevention, and treatment of this disease. With further research and experimentation, the role of airway epithelial cells in COPD can be enhanced, leading to the development of novel and more effective strategies to combat this condition.
Material and methods: The role of airway epithelial cells in COPD was investigated in this study using transcriptome data modeling. Transcriptome samples from non-smoker groups and patients at different stages of the disease were analyzed, and functional modules were identified using gene co-expression network analysis and gene regulatory network plotting methods.
Results: The genes PLAG1, CYP4Z1, ME1, MUCL1, and TLR5 have the highest betweenness centrality scores and the genes CYP4Z1, PLAG1, SLITRK6, GLI3, and CABYR have the highest degrees in the resulting functional cluster.
Conclusion: A better understanding of the biological mechanisms and contributing factors in COPD may help to develop to new approaches for diagnosis, prevention, and treatment of this disease. With further research and experimentation, the role of airway epithelial cells in COPD can be enhanced, leading to the development of novel and more effective strategies to combat this condition.
Type of Study: Research Article |
Subject:
Cellular and molecular
Received: 2024/12/4 | Accepted: 2024/09/22 | Published: 2024/09/22
Received: 2024/12/4 | Accepted: 2024/09/22 | Published: 2024/09/22
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