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Koohi Moftakhari Esfahani M, Alavi S E, akbarzadeh A. Drug delivery of pegylated nanoliposomal paclitaxel to breast cancer cell line. NCMBJ 2014; 4 (14) :47-50
URL: http://ncmbjpiau.ir/article-1-518-en.html

Materials and Methods: In order to produce pegylated nanoliposomal certain proportions of phosphatidylcholine, cholesterol, polyethylene glycol and paclitaxel were mixed together. The mean diameter of pegylated nanoliposomal paclitaxel was determined by Zeta sizer system. The encapsulation efficiency was calculated using standard curve. The percent of drug released from pegylated nanoliposomes was performed by dialysis for 28 hours. Also, cytotoxicity of pegylated nanoliposomal paclitaxel was studied through MTT technique. 

Results: The particles’ mean diameter confirmed in nano dimensions. Encapsulation efficiency and drug release of pegylated nanoliposomal paclitaxel was 95.2±6.3% and 5.02, respectively. Results showed an increase in toxicity, the formulation was prepared. 

Conclusion: Polyethylene glycol causes more stability and slower release of drug.