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Aim & Background: Frankincense is a herbal product that has diverse therapeutic effects. Beta-boswellic acid, the main ingredient of frankincense, is poorly soluble in water and its bioavailability is very low. The aim of present study was to evaluate the effect of loading of beta-boswellic acid in dendrosomal nanoparticles on its bioavailability and cell uptake by MTT assay. Materials and Methods: For MTT assay, B65 cells were treated with different doses of nave beta-boswellic acid or dendrosomal beta-boswelic acid for 24, 48 and 72 hours. After adding MTT, colorimetery was done using ELISA reader and IC50 was then calculated. The data was analyzed with One Way Anova program using SPSS v.16 software. Results: The IC50 for nave beta-boswellic acid and dendrosomal beta-boswellic acid was 88/09 and 58/42 µM in 24h, 58/37 and 44/87 µM in 48h and 21/09 and 16/69 µM in 72h respectively. Conclusion: The results showed that loading of beta-boswellic acid in dendrosomal nanoparticles increases the cell toxicity effect of beta-boswellic acid. This observation might be due to the increased cell uptake of beta-boswellic acid in the presence of dendrosomal nanoparticles.

Keywords: beta- Boswellic acid, Dendrosome, MTT test, B65 cell line

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